Showing papers by "Rakesh K. Jain published in 1981"
TL;DR: The model developed here possesses, at least from a qualitative point of view, two important properties of observable growth kinetics: cell debris is required for the neovascularization to begin, and vessel density exhibits a maximum before reaching the steady-state value.
102 citations
TL;DR: The model provides adequate simulations of the zinc concentration and excretion data after the intravenous injection of65ZnSO4 and is essential to develop a more comprehensive model to quantify zinc speciation and binding.
Abstract: A whole body pharmacokinetic model to quantify zinc uptake, distribution, and excretion in rats is developed. The novel features of the model are the large number of tissues which are included (17 tissues, plasma, and red blood cells) and the long time range (3 weeks) over which the data are simulated. The model provides adequate simulations (average error less than 10%) of the zinc concentration and excretion data after the intravenous injection of65ZnSO4. A model of this type is essential to develop a more comprehensive model to quantify zinc speciation and binding.
44 citations
TL;DR: A physical map of the rRNA gene from the ciliated protozoan Tetrahymena pyriformis has been determined and DNA fragments generated by digestion with each endonuclease were ordered into a unique sequence.
Abstract: A physical map of the rRNA gene from the ciliated protozoan Tetrahymena pyriformis has been determined. The isolated rDNA palindrome was labeled by nick translation and digested with the sequence-specific endonucleases KpnI, BclI, PvuII, PstI, SstI, AvaI, AvaII, HpaI, BamHI, Bg/II, or HindIII, and the molecular weights of the products were determined by gel electrophoresis. The DNA fragments generated by digestion with each endonuclease were ordered into a unique sequence either by analyzing the products produced by concomitant cleavage with one or more additional restriction enzymes or by hybridizing to 17S and 25S rRNA. Hybridization of the 35S rRNA primary transcription product to HindIII and BamHI restriction fragments localizes the promoter to the left of 16.9% and the terminator to the region between 71.6% and 78% on the physical map.
9 citations
1 citations