R
Rakesh K. Jain
Researcher at Harvard University
Publications - 1528
Citations - 198912
Rakesh K. Jain is an academic researcher from Harvard University. The author has contributed to research in topics: Angiogenesis & Cancer. The author has an hindex of 200, co-authored 1467 publications receiving 177727 citations. Previous affiliations of Rakesh K. Jain include Government Medical College, Thiruvananthapuram & University of Oslo.
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Journal ArticleDOI
Delivery of molecular and cellular medicine to solid tumors
TL;DR: A paradigm of analysis and synthesis has allowed us to obtain a better understanding of physiological barriers in solid tumors, and to develop novel strategies to exploit and/or to overcome these barriers for improved cancer detection and treatment.
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Diffusion and convection in collagen gels: implications for transport in the tumor interstitium.
Saroja Ramanujan,Alain Pluen,Trevor D. McKee,Trevor D. McKee,Edward B. Brown,Yves Boucher,Rakesh K. Jain,Rakesh K. Jain +7 more
TL;DR: Comparison of diffusion and convection data in these gels and tumors suggests that collagen may obstruct diffusion more than convection in tumors, which has significant implications for drug delivery in tumors and for tissue engineering applications.
Journal Article
Microvascular Pressure Is the Principal Driving Force for Interstitial Hypertension in Solid Tumors: Implications for Vascular Collapse
Yves Boucher,Rakesh K. Jain +1 more
TL;DR: The results demonstrate that the main driving force for IFP in tumors is the MVP, and the concept that blood vessel collapse is induced by higher hydrostatic pressures in the tumor interstitium compared to that in the vascular lumen is not supported.
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Vascular and interstitial barriers to delivery of therapeutic agents in tumors.
TL;DR: If the genetically engineered macromolecules and effector cells, as well as low molecular weight cytotoxic agents, are to fulfill their clinical promise, strategies must be developed to overcome or exploit these barriers.
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Microvascular architecture in a mammary carcinoma: branching patterns and vessel dimensions.
TL;DR: Solid tumor vascular architecture, while exhibiting several features that are similar to those observed innormal tissues, has others that are not commonly seen in normal tissues, thus reducing the efficacy of present day cancer therapies.