Rakesh K. Jain

TL;DR: The results suggest that the presence of platelets not only stimulates angiogenic vessel growth but also plays a critical role in preventing hemorrhage from theAngiogenic vessels of Matrigel.

TL;DR: This work optically measured interstitial pH gradients with high resolution in normal and tumor (VX2 carcinoma) tissue in vivo by combining a fluorescence ratio imaging microscopy technique and the rabbit ear chamber preparation to permit noninvasive evaluation of new pH-modifying agents and offer unique mechanistic information about tumor pathophysiology.

TL;DR: Differential flow response in individual microvessels was used to develop a theoretical framework relating various mechanisms of blood flow modifications due to hyperthermia, which appeared to be bimodal functions of temperature.

TL;DR: Values of D/D infinity calculated from this effective medium theory, without use of adjustable parameters, were in much better agreement with the measured values than were predictions based on other approaches.

TL;DR: Total neoadjuvant therapy with FOLFIRINOX, losartan, and chemoradiotherapy provides downstaging of locally advanced pancreatic ductal adenocarcinoma and is associated with an R0 resection rate of 61%.