R
Rakesh K. Jain
Researcher at Harvard University
Publications - 1528
Citations - 198912
Rakesh K. Jain is an academic researcher from Harvard University. The author has contributed to research in topics: Angiogenesis & Cancer. The author has an hindex of 200, co-authored 1467 publications receiving 177727 citations. Previous affiliations of Rakesh K. Jain include Government Medical College, Thiruvananthapuram & University of Oslo.
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Edema Control by Cediranib, a Vascular Endothelial Growth Factor Receptor–Targeted Kinase Inhibitor, Prolongs Survival Despite Persistent Brain Tumor Growth in Mice
Walid S. Kamoun,Carsten D. Ley,Christian T. Farrar,Annique M M J Duyverman,Johanna Lahdenranta,Delphine A. Lacorre,Tracy T. Batchelor,Emmanuelle di Tomaso,Dan G. Duda,Lance L. Munn,Dai Fukumura,A. Gregory Sorensen,Rakesh K. Jain +12 more
TL;DR: By controlling edema, cediranib significantly increased survival of mice in the face of persistent tumor growth, suggesting anti-VEGF agents may be able to improve survival of patients with glioblastoma, even without inhibiting tumor growth.
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Physical traits of cancer.
TL;DR: The authors provide a conceptual framework and discuss the origins of these distinct physical traits of cancer and how they enable and synergize with aberrant cancer biology to fuel cancer initiation, progression, immune evasion, and treatment resistance.
Journal Article
Vascular Endothelial Growth Factor Receptor-2-blocking Antibody Potentiates Radiation-induced Long-Term Control of Human Tumor Xenografts
TL;DR: The encouraging results on two human tumor xenografts suggest that vascular endothelial growth factor receptor-2 blockade merits further investigation to assess its potential as an enhancer of radiation therapy in the clinic.
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Ethnopharmacologic investigation of ginger (Zingiber officinale).
TL;DR: An ethanolic extract of the rhizomes of Zingiber officinale was investigated for anti-inflammatory, analgesic, antipyretic, antimicrobial and hypoglycaemic activities in rats and rabbits and was ineffective in suppressing the writhing induced by intraperitoneal acetic acid.
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Delivery of molecular medicine to solid tumors: lessons from in vivo imaging of gene expression and function.
TL;DR: A better understanding of microcirculatory barriers in solid tumors is obtained and novel strategies to exploit and/or to overcome these barriers for improved cancer detection and treatment are developed.