R
Rakesh K. Jain
Researcher at Harvard University
Publications - 1528
Citations - 198912
Rakesh K. Jain is an academic researcher from Harvard University. The author has contributed to research in topics: Angiogenesis & Cancer. The author has an hindex of 200, co-authored 1467 publications receiving 177727 citations. Previous affiliations of Rakesh K. Jain include Government Medical College, Thiruvananthapuram & University of Oslo.
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Journal ArticleDOI
Principles and mechanisms of vessel normalization for cancer and other angiogenic diseases
Peter Carmeliet,Rakesh K. Jain +1 more
TL;DR: Preclinical and initial clinical evidence reveal that normalization of the vascular abnormalities is emerging as a complementary therapeutic paradigm for cancer and other vascular disorders, which affect more than half a billion people worldwide.
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Angiogenesis in brain tumours
Rakesh K. Jain,Emmanuelle di Tomaso,Dan G. Duda,Jay S. Loeffler,A. Gregory Sorensen,Tracy T. Batchelor +5 more
TL;DR: Emerging preclinical and clinical data indicate that anti-VEGF therapies are potentially effective in glioblastoma and can transiently normalize tumour vessels, creating a window of opportunity for optimally combining chemotherapeutics and radiation.
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Hyperplasia of lymphatic vessels in VEGF-C transgenic mice
Michael Jeltsch,Arja Kaipainen,Arja Kaipainen,Vladimir Joukov,Vladimir Joukov,Xiaojuan Meng,Xiaojuan Meng,Merja Lakso,Merja Lakso,Heikki Rauvala,Heikki Rauvala,Melody A. Swartz,Melody A. Swartz,Dai Fukumura,Dai Fukumura,Rakesh K. Jain,Rakesh K. Jain,Kari Alitalo,Kari Alitalo +18 more
TL;DR: VEGF-C induces selective hyperplasia of the lymphatic vasculature, which is involved in the draining of interstitial fluid and in immune function, inflammation, and tumor metastasis, and may be of potential use in therapeutic lymphangiogenesis.
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Normalization of the vasculature for treatment of cancer and other diseases
TL;DR: The pathophysiology of tumor angiogenesis, the molecular underpinnings and functional consequences of vascular normalization, and the implications for treatment of cancer and nonmalignant diseases are reviewed.
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Challenges and Key Considerations of the Enhanced Permeability and Retention Effect for Nanomedicine Drug Delivery in Oncology
Uma Prabhakar,Hiroshi Maeda,Rakesh K. Jain,Eva M. Sevick-Muraca,William C. Zamboni,Omid C. Farokhzad,Simon T. Barry,Alberto Gabizon,Piotr Grodzinski,David C. Blakey +9 more
TL;DR: This report summarizes the workshop discussions on key issues of the EPR effect and major gaps that need to be addressed to effectively advance nanoparticle-based drug delivery.