Rakesh K. Jain

TL;DR: Two simple measures of vascular geometry—δmax and λ—readily obtained from vascular images, capture differences and link vascular structure to delivery in both tissue types and are useful for evaluating how new therapeutic agents that inhibit or stimulate vascular growth alter the functional efficiency of the vasculature.

TL;DR: This model offers an explicit, low-order parameterization, enabling joint estimation of boundary, centerlines, and local pose, and provides a geometric framework for directed vessel traversal, and extraction of topological information like branch point locations and connectivity.

TL;DR: It is shown that TB-infected rabbits have impaired small molecule distribution into these disease sites due to a functionally abnormal vasculature, with a low-molecular-weight tracer accumulating only in peripheral regions of granulomatous lesions.

TL;DR: In this paper, the stability of thin (100 nm) symmetrical and unsymmetrical membranes, assimilated with viscous liquids, to short and long wavelength perturbations is investigated.

TL;DR: The results show that the behavior of microcirculation may be strongly modified as a result of vascular compliance and enhanced vascular leakiness of tumor vessels, and that drug delivery for chemotherapy and oxygenation needed for radiotherapy may well be hampered in the central region of the tumor, despite the presence of highly permeable vessels in these regions.