Rakesh K. Jain

TL;DR: Comparison of in vitro vs in vivo results suggests an over-riding role of host stromal cells in extracellular matrix production subjected to modulation by tumour cells, which might mean that caution must be exercised in extrapolating drug penetrability from spheroids and multilayer cellular sandwiches consisting of only tumours to tumours in vivo.

TL;DR: The development and validation of a mathematical model based on the sedimentation rate and velocity profile in the chamber for the delivery of cells from a flowing suspension to the chamber surface and results show that the flux depends on the bulk cell concentration, the distance from the entrance point, and the flow rate of the cell-containing medium.

TL;DR: Acute lymphedema developing after ligation of tail lymphatics in mice can be prevented by myocutaneous flap transfer and restored lymphatic continuity and function were demonstrable using lymphoscintigraphy and fluorescence microlymphangiography.

TL;DR: How reprogramming various facets of the TME (blood vessels, myeloid cells, and regulatory T cells [Tregs]) may overcome TME-instigated resistance mechanisms to immunotherapy is discussed.

TL;DR: The ATR index did not provide a useful prediction of response to combination treatment, but may prove useful in predicting responsiveness to different antidepressant medications.