Rakesh K. Jain

TL;DR: Emerging data show that the function of blood vessels associated with tumors is critical in the response to these immunotherapies and improving vascular function provides opportunities to enhance immunotherapy.

TL;DR: The results establish the utility of the QD-micelle approach for in vivo biological sensing applications and provide a means for signal transduction under both one- and two-photon excitation.

TL;DR: It is shown that a subgroup of primary and metastatic brain tumours, classified as nodular on the basis of their growth pattern, exert solid stress on the surrounding brain tissue, causing a decrease in local vascular perfusion as well as neuronal death and impaired function, and that lithium as a therapeutic intervention could counter these effects.

TL;DR: MMP14 blockade decreased immunosuppressive TGFβ, polarized macrophages to an antitumor phenotype, increased iNOS, and improved tumor perfusion, resulting in reduced primary tumor growth and enhanced response to radiation therapy, especially in high MMP14-expressing tumors.

TL;DR: It is demonstrated that pharmacological VE-PTP inhibition can normalize the structure and function of tumor vessels through Tie-2 activation, which delays tumor growth, slows metastatic progression, and enhances response to concomitant cytotoxic treatments.