R
Rakesh K. Jain
Researcher at Harvard University
Publications - 1528
Citations - 198912
Rakesh K. Jain is an academic researcher from Harvard University. The author has contributed to research in topics: Angiogenesis & Cancer. The author has an hindex of 200, co-authored 1467 publications receiving 177727 citations. Previous affiliations of Rakesh K. Jain include Government Medical College, Thiruvananthapuram & University of Oslo.
Papers
More filters
Journal ArticleDOI
Reengineering the Tumor Vasculature: Improving Drug Delivery and Efficacy
TL;DR: Engineers and physical scientists have developed a number of strategies to reengineer the tumor microenvironment to overcome barriers and thus improve delivery and efficacy of treatments and have the potential to improve the treatment outcome for many diseases characterized by an abnormal microenvironment.
Journal Article
Imaging of Activated Natural Killer Cells in Mice by Positron Emission Tomography: Preferential Uptake in Tumors
TL;DR: P positron emission tomography may be used to quantify the number of effector cells which accumulate within tumors and to determine their biodistribution and the preferential accumulation of effectors in the tumor vasculature following local injection has useful implications for adoptive immunotherapy.
Journal ArticleDOI
Phase II and Biomarker Study of Cabozantinib in Metastatic Triple-Negative Breast Cancer Patients.
Sara M. Tolaney,David R. Ziehr,Hao Guo,Mei Rosa Ng,William T. Barry,Michaela J. Higgins,Steven J. Isakoff,Jane E. Brock,Elena Ivanova,Cloud P. Paweletz,Michelle Demeo,Nikhil H. Ramaiya,Beth Overmoyer,Rakesh K. Jain,Eric P. Winer,Dan G. Duda +15 more
TL;DR: Exploratory analyses of circulating biomarkers showed that cabozantinib induces systemic changes consistent with activation of the immune system and antiangiogenic activity, and soluble MET should be further evaluated as a potential biomarker of response.
Journal ArticleDOI
Wide-field three-photon excitation in biological samples
Christopher J. Rowlands,Demian Park,Oliver T. Bruns,Kiryl D. Piatkevich,Dai Fukumura,Rakesh K. Jain,Moungi G. Bawendi,Edward S. Boyden,Peter T. C. So +8 more
TL;DR: Functional excitation is demonstrated by performing three-photon optogenetic stimulation of cultured mouse hippocampal neurons expressing a channelrhodopsin; action potentials could reliably be excited without causing photodamage.
Journal ArticleDOI
Efficacy, Safety, Pharmacokinetics, and Biomarkers of Cediranib Monotherapy in Advanced Hepatocellular Carcinoma: A Phase II Study
Andrew X. Zhu,Marek Ancukiewicz,Jeffrey G. Supko,Dushyant V. Sahani,Lawrence S. Blaszkowsky,Jeffrey A. Meyerhardt,Thomas A. Abrams,Nadine Jackson McCleary,Pankaj Bhargava,Alona Muzikansky,Susan Sheehan,Eileen Regan,Eamala Vasudev,Michelle Knowles,Charles S. Fuchs,David P. Ryan,Rakesh K. Jain,Dan G. Duda +17 more
TL;DR: Cediranib at 30-mg daily showed a high incidence of toxicity and preliminary evidence of antitumor activity in advanced HCC, and proangiogenic and inflammatory factors as potential biomarkers of anti-VEGF therapy in HCC.