Rakesh K. Singh

TL;DR: The aspects of metabolic disorders-induced oxidative stress in major pathological conditions and strategies for their prevention and therapy are discussed.

TL;DR: It is demonstrated that excess histones associate with Rad53 in vivo and seem to undergo modifications such as tyrosine phosphorylation and polyubiquitylation, before their proteolysis by the proteasome, which has major implications for the maintenance of epigenetic marks on chromatin, genomic stability and the packaging of sperm DNA.

TL;DR: In this paper, the authors provided the largest proteomic profile of extracellular vesicles (EVs) in a single study, identifying 6,071 proteins with 213 common to all isolates.

TL;DR: Evidence is presented that excess histones are likely to mediate their cytotoxic effects via multiple mechanisms that are primarily dependent on inappropriate electrostatic interactions between the positively charged histones and diverse negatively charged molecules in the cell.

TL;DR: Results support the usefulness of serum exosomes to noninvasively detect inflammatory phenotype and to discover novel biomarkers associated with PCa in African American men.