Rakesh K. Singh

TL;DR: The data suggest that IL-8 directly enhanced endothelial cell proliferation, survival, and MMP expression in CX CR1- and CXCR2-expressing endothelial cells and regulated angiogenesis.

TL;DR: It is recommended that future studies incorporate orthotopic and spontaneous metastasis models (syngeneic and xenogenic) because they incorporate microenvironmental interactions, in addition to confirmatory autochthonous models and/or genetically engineered models, for molecular therapeutics.

TL;DR: Investigation of the influence of interferons alpha, beta, and gamma (IFN-alpha, -beta, and -gamma) on the production of basic fibroblast growth factor (bFGF) by human renal carcinoma cells found down-regulated the expression of bFGF at the mRNA and protein levels by a mechanism independent of their antiproliferative effects.

TL;DR: Enforced expression of IL-8 rendered the melanoma cells highly tumorigenic and increased their metastatic potential as compared with parental and control transfected cells, suggesting thatIL-8 is involved in MMP-2 gene transcription.

TL;DR: It is suggested that inhibition of MMP-7 will have therapeutic benefit in the treatment of prostate cancer-induced osteolysis.