R
Ralph A. Sperling
Researcher at University of Marburg
Publications - 36
Citations - 5440
Ralph A. Sperling is an academic researcher from University of Marburg. The author has contributed to research in topics: Colloidal gold & Nanoparticle. The author has an hindex of 18, co-authored 33 publications receiving 5070 citations. Previous affiliations of Ralph A. Sperling include Center for NanoScience & Ludwig Maximilian University of Munich.
Papers
More filters
Journal ArticleDOI
Biological applications of gold nanoparticles
TL;DR: This critical review gives a short overview of the widespread use of gold nanoparticles in biology, identifying four classes of applications in which gold nanoparticle have been used so far: labelling, delivering, heating, and sensing.
Journal ArticleDOI
Synthesis, Characterization, and Bioconjugation of Fluorescent Gold Nanoclusters toward Biological Labeling Applications
Cheng-An J. Lin,Ting-Ya Yang,Chih-Hsien Lee,Sherry H. Huang,Ralph A. Sperling,Marco Zanella,Jimmy K. Li,Ji-Lin Shen,Hsueh-Hsiao Wang,Hung-I Yeh,Wolfgang J. Parak,Walter H. Chang +11 more
TL;DR: Synthesis of ultrasmall water-soluble fluorescent gold nanoclusters has a decent quantum yield, high colloidal stability, and can be readily conjugated with biological molecules.
Journal ArticleDOI
Biodistribution of PEG-modified gold nanoparticles following intratracheal instillation and intravenous injection
Jens Lipka,Manuela Semmler-Behnke,Ralph A. Sperling,Alexander Wenk,Shinji Takenaka,Carsten Schleh,Thomas Kissel,Wolfgang J. Parak,Wolfgang G. Kreyling +8 more
TL;DR: This study investigated the biokinetics after intravenous and intratracheal applications of poly(ethylene glycol) modified Au NPs compared to plain Au N Ps and found the majority of all three types of applied NPs stayed in the lungs.
Journal ArticleDOI
Design of an Amphiphilic Polymer for Nanoparticle Coating and Functionalization
Cheng-An J. Lin,Ralph A. Sperling,Ralph A. Sperling,Jimmy K. Li,Jimmy K. Li,Ting-Ya Yang,Pei-Yun Li,Marco Zanella,Marco Zanella,Walter H. Chang,Wolfgang J. Parak,Wolfgang J. Parak +11 more
TL;DR: The amphiphilic polymer described here is based on a poly(maleic anhydride) backbone which involves a third kind of building block: functional organic molecules and provides additional functionality in the particle surface.
Journal ArticleDOI
Size and surface effects on the MRI relaxivity of manganese ferrite nanoparticle contrast agents.
Ulrich I. Tromsdorf,Nadja C. Bigall,Michael G. Kaul,Oliver T. Bruns,Marija Nikolic,Birgit Mollwitz,Ralph A. Sperling,Rudolph Reimer,Heinz Hohenberg,Wolfgang J. Parak,Stephan Förster,Ulrike Beisiegel,Gerhard Adam,Horst Weller +13 more
TL;DR: Superparamagnetic MnFe2O4 nanocrystals of different sizes were synthesized in high-boiling ether solvent and transferred into water using three different approaches and an increase in transverse relaxivities with increasing particle size for the polymer-coated nanocrystal is observed.