R
Ralph B. D'Agostino
Researcher at Wake Forest University
Publications - 1336
Citations - 250792
Ralph B. D'Agostino is an academic researcher from Wake Forest University. The author has contributed to research in topics: Framingham Heart Study & Framingham Risk Score. The author has an hindex of 226, co-authored 1287 publications receiving 229636 citations. Previous affiliations of Ralph B. D'Agostino include VA Boston Healthcare System & University of Illinois at Urbana–Champaign.
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Journal ArticleDOI
Out-of-Hospital Administration of Intravenous Glucose-Insulin-Potassium in Patients With Suspected Acute Coronary Syndromes: The IMMEDIATE Randomized Controlled Trial
Harry P. Selker,Joni R. Beshansky,Patricia R. Sheehan,Joseph M. Massaro,John L. Griffith,Ralph B. D'Agostino,Robin Ruthazer,James M Atkins,Assaad Sayah,Michael Levy,Michael E. Richards,Tom P. Aufderheide,Darren Braude,Ronald G. Pirrallo,Delanor D. Doyle,Ralph J. Frascone,Donald J. Kosiak,James M. Leaming,Carin M. Van Gelder,Gert Paul Walter,Marvin A. Wayne,Robert Woolard,Lionel H. Opie,Charles E. Rackley,Carl S. Apstein,James E. Udelson +25 more
TL;DR: In this article, an out-of-hospital emergency medical service (EMS) administration of intravenous glucose-insulin-potassium (GIK) in the first hours of suspected acute coronary syndromes (ACS) was tested.
Journal ArticleDOI
Challenges in the Design and Interpretation of Noninferiority Trials
Laura Mauri,Ralph B. D'Agostino +1 more
TL;DR: In this review, the authors consider the characteristics and challenges of noninferiority trial designs, including seven essential features of non-inferIORity trials.
Journal ArticleDOI
Genetic correlates of brain aging on MRI and cognitive test measures: a genome-wide association and linkage analysis in the Framingham study
Sudha Seshadri,Sudha Seshadri,Anita L. DeStefano,Anita L. DeStefano,Rhoda Au,Rhoda Au,Joseph M. Massaro,Joseph M. Massaro,Alexa S. Beiser,Alexa S. Beiser,Margaret Kelly-Hayes,Margaret Kelly-Hayes,Carlos S. Kase,Carlos S. Kase,Ralph B. D'Agostino,Ralph B. D'Agostino,Charles DeCarli,Larry D. Atwood,Larry D. Atwood,Philip A. Wolf,Philip A. Wolf +20 more
TL;DR: The results suggest that genes associated with clinical neurological disease also have detectable effects on subclinical phenotypes, and illustrate the use of an unbiased approach to discover novel pathways that may be involved in brain aging.
Journal ArticleDOI
Secular Trends in Long-term Sustained Hypertension, Long-term Treatment, and Cardiovascular Mortality The Framingham Heart Study 1950 to 1990
TL;DR: This investigation of LTS hypertension, its treatment, and its sequelae in a free-living general population confirms the reduction in CVD mortality demonstrated in more short-term clinical trials of hypertension therapy in select patient groups.
Journal ArticleDOI
Genetic correlates of longevity and selected age-related phenotypes: a genome-wide association study in the Framingham Study
Kathryn L. Lunetta,Kathryn L. Lunetta,Ralph B. D'Agostino,Ralph B. D'Agostino,David Karasik,Emelia J. Benjamin,Emelia J. Benjamin,Chao-Yu Guo,Chao-Yu Guo,Raju Govindaraju,Raju Govindaraju,Douglas P. Kiel,Margaret Kelly-Hayes,Margaret Kelly-Hayes,Joseph M. Massaro,Joseph M. Massaro,Michael J. Pencina,Michael J. Pencina,Sudha Seshadri,Sudha Seshadri,Joanne M. Murabito,Joanne M. Murabito +21 more
TL;DR: Longevity and aging traits are associated with SNPs on the Affymetrix 100K SNP GeneChip and none of the associations achieved genome-wide significance.