R
Ralph B. D'Agostino
Researcher at Wake Forest University
Publications - 1336
Citations - 250792
Ralph B. D'Agostino is an academic researcher from Wake Forest University. The author has contributed to research in topics: Framingham Heart Study & Framingham Risk Score. The author has an hindex of 226, co-authored 1287 publications receiving 229636 citations. Previous affiliations of Ralph B. D'Agostino include VA Boston Healthcare System & University of Illinois at Urbana–Champaign.
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Journal ArticleDOI
Behavioral stress accelerates prostate cancer development in mice
Sazzad Hassan,Yelena Karpova,Daniele Baiz,Dana Yancey,Ashok K. Pullikuth,Anabel Flores,Thomas C. Register,J. Mark Cline,Ralph B. D'Agostino,Nika N. Danial,Sandeep Robert Datta,George Kulik +11 more
TL;DR: It is reported that stress promotes prostate carcinogenesis in mice in an adrenaline-dependent manner and interactions between prostate tumors and the psychosocial environment mediated by activation of an adrenaline/ADRB2/PKA/BAD antiapoptotic signaling pathway are demonstrated.
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Insomnia Severity is an Indicator of Suicidal Ideation During a Depression Clinical Trial
W. Vaughn McCall,Jill N. Blocker,Ralph B. D'Agostino,James Kimball,Niki Boggs,Barbara Lasater,Peter B. Rosenquist +6 more
TL;DR: The results support the concept that insomnia may be a useful indicator for suicidal ideation and now extend this idea into clinical trials.
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Combining single patient (N-of-1) trials to estimate population treatment effects and to evaluate individual patient responses to treatment.
Deborah R. Zucker,Christopher H. Schmid,Martin W. McIntosh,Ralph B. D'Agostino,Harry P. Selker,Joseph Lau +5 more
TL;DR: A hierarchical Bayesian random effects model is presented to combine N-of-1 studies to obtain an estimate of treatment effectiveness for the population and to use this population information to aid in the evaluation of an individual patient's trial results.
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Framingham Heart Study 100K project: genome-wide associations for cardiovascular disease outcomes
Martin G. Larson,Martin G. Larson,Larry D. Atwood,Larry D. Atwood,Emelia J. Benjamin,Emelia J. Benjamin,L. Adrienne Cupples,L. Adrienne Cupples,Ralph B. D'Agostino,Ralph B. D'Agostino,Caroline S. Fox,Diddahally R. Govindaraju,Diddahally R. Govindaraju,Chao-Yu Guo,Chao-Yu Guo,Nancy L. Heard-Costa,Nancy L. Heard-Costa,Shih-Jen Hwang,Joanne M. Murabito,Joanne M. Murabito,Christopher Newton-Cheh,Christopher Newton-Cheh,Christopher Newton-Cheh,Christopher J. O'Donnell,Christopher J. O'Donnell,Sudha Seshadri,Sudha Seshadri,Ramachandran S. Vasan,Ramachandran S. Vasan,Thomas J. Wang,Thomas J. Wang,Philip A. Wolf,Philip A. Wolf,Daniel Levy +33 more
TL;DR: A community-based genome-wide association study of major CVD outcomes finds genetic variants associated with CVD may point to novel disease pathways and identify potential targeted preventive therapies.
Journal ArticleDOI
Risk of Hospitalized Stroke in Men Enrolled in the Honolulu Heart Program and the Framingham Study A Comparison of Incidence and Risk Factor Effects
Beatriz L. Rodriguez,Ralph B. D'Agostino,Robert D. Abbott,Abraham Kagan,Cecil M. Burchfiel,Katsuhiko Yano,G. Webster Ross,Halit Silbershatz,Millicent Higgins,Jordan Popper,Philip A. Wolf,J. David Curb +11 more
TL;DR: The authors compared the 20-year incidence of hospitalized stroke between Japanese-American men in the Honolulu Heart Program and white men in Framingham Study and found that Framingham men had a 40% excess of thromboembolic stroke compared with Honolulu men after adjustment for age and other risk factors (62/1000 versus 45/1000, respectively, P<0.001), whereas incidence of hemorrhagic stroke was nearly identical (14.8/100...