Ramazan Ulus

TL;DR: In this paper, an efficient, high yielding, quick method has been developed for the synthesis of acridinedione derivatives via a one-pot, multi-component condensation of dimedone (1), various aromatic aldehydes (2), and various aromatic amines (3a,b) using highly monodisperse platinum nanoparticles supported with reduced graphene oxide (Pt NPs@rGO) as a recyclable heterogeneous catalyst.

TL;DR: The structure-activity relationships for the inhibition of these isoforms with the acridine-sulfonamides reported here were elucidated and more precisely the cytosolic isoforms hCA I, II and VII.

TL;DR: In this article, carboxylic acid groups were immobilized onto carbon nanotubes and their catalytic properties were examined for the first time for the synthesis of acridinedione derivatives, opening new paths in the investigation of catalysis and their comparison with carbon-based materials.

TL;DR: Reaction of dimedone, 4-amino-N-(diaminomethylene)benzenesulfonamide, and aromatic aldehydes was successfully realized using sulfuric acid as a cheap catalyst and synthesis of novel acridine sulfonamide compounds was performed providing high yields in water as the solvent at room temperature.

TL;DR: By using a multi component reaction system (MCR), nitro acridine sulfonamides were obtained from cyclic-1,3-diketones, 4-aminobenzene sulfonamide and aromatic aldehydes and showed low micromolar inhibition against the medically relevant isoforms hCA I, II, IX, and XII.