Rambabu Sharma

Bio: Rambabu Sharma is an academic researcher from Jodhpur National University. The author has contributed to research in topics: Medicine & Benzimidazole. The author has an hindex of 3, co-authored 20 publications receiving 116 citations.

A review on: hiv aids

Abstract: HIV/AIDS has always been one of the most thoroughly global of diseases. The human immunodeficiency virus (HIV) is a lent virus that causes HIV infection and AIDS. AIDS is a condition in humans in which progressive failure of the immune system allows life-threatening infections and cancers to thrive. Infection with HIV occurs by the transfer of blood, semen, vaginal fluid, breast milk. Within these bodily fluids, HIV is present as both free virus particles and virus within infected immune cells. HIV infects vital cells in the human immune system such as helper CD4 T cells, macrophages. HIV infection leads to low levels of T cells through a number of mechanisms, including pyroptosis of infected T cells. The symptoms of AIDS are primarily the result of conditions that do not normally develop in individuals with healthy immune systems. Most of these conditions are opportunistic infections caused by bacteria, viruses, fungi and parasites that are normally controlled by the elements of the immune system that HIV damages. When condoms are used consistently by a couple in which one person is infected, the rate of HIV infection is less than 1% per year. There is some evidence to suggest that female condoms may provide an equivalent level of protection.

Peak expiratory flow rates in children of western rajasthan 7-14 years of age

Abstract: Background: A lot of age-specific variations in Peak Expiratory Flow Rate (PEFR) are expected in paediatrics age group compared to adults. Therefore availability of normal values for different age group is absolutely essential for logical interpretation of PEFR. Only few studies are available on ventilator functions for children of Western Rajasthan (a desert area) 7–14 years of Age. Method: One hundred and eighty-eight apparently healthy school children (112 Male, 76 Female) from age group 7–14 years were included in the study. PEFR was measured in L/min with a standard Wright Peak Flow Meter. Result: Positive correlation was seen between age, height, weight, Body surface area, and PEFR. The regression equations for PEFR were determined for boys and girls separately. The prediction equation for PEFR based on Weight was PEFR=71.519+weight×4.202 (for boys) PEFR=115.081+weight×1.406 (for girls). Predicted formulas obtained by regression equation for Age were: PEFR=27.442+Age×17.289 (for boys), PEFR=83.88+Age×7.399 (for girls). Predicted formulas obtained by regression equation for height were: PEFR= -166.592+Height×2.653 (for boys) PEFR= -50.24+Height×1.501 (for girls). Predicted formulas for PEFR obtained by regression equation for BSA were: PEFR=42.483+BSA×159.983 (for boys), PEFR=99.714+BSA×59.505 (for girls). In both male and female children, PEFR significantly increases (p<0.05) with height, weight, age, and Body Surface Area (BSA). Conclusion: PEFR is a reliable measurement, which can be used in desert areas of Western Rajasthan for assessment of airway obstruction. Prediction formula is derived for use in this population.

Duration of Viral Clearance in Children With SARS-CoV-2 Infection in Rajasthan, India.

Abstract: Objective To study the clinical and laboratory profile and to assess period for viral clearance in COVID 19 children. Method We reviewed hospital records of children ( Results 81.2% of the 85 children studied were asymptomatic and 3 (8.5%) died. Severe lymphopenia (43.8%), raised C-reactive protein (93.8%), raised erythrocyte sedimentation rate (75%) and high (>500ng/mL) levels of D-dimer (37.5%) were common. Median (IQR) duration of viral shedding was 7 (5-10) days, with range of 2 to 45 days; 96.3% had viral clearance within 14 days. Conclusions Majority of children aged

Evaluation of consanguinity as a risk factor for congenital heart diseases

Abstract: Background: Congenital heart disease (CHD) is the most common malformation in children. It is an important cause of infant mortality, long term morbidity and disability. There are multiple risk factors associated with CHDs, but in most of them cause and effect relationship has not been established till recently. Consanguinity as a risk factor has been studied by some workers with a small number of subjects hence requires to be evaluated through a study with a significant size of cohort. The objective of the study was to find out the association between parental consanguinity and the risk of CHDs among their off springs. Methods: This is a hospital based, comparative, cross sectional, observational study. 518 children with CHDs, confirmed by echocardiography were included as cases and 240 children without any obvious congenital anomaly matched for age and sex were taken as control. The following clinical observations were collected through questionnaires in a predesigned performa: maternal and paternal age at conception; parental consanguinity; maternal medical, gestational and obstetric history; and other birth defects. Results: Children from case and control groups were comparable with respect to age and sex at the inclusion in the study. Out of the total 758 study participants, 41 patients (5.41%) had parents who had a consanguineous marriage. Of these, 34 patients (6.56%) were cases and 7 (2.92%) were controls (P value was highly significant). Conclusions: Consanguinity in parental marriages confer an increased risk of CHDs in their off springs (p value <0.005).

Medicinal significance of benzothiazole scaffold: an insight view

Abstract: Heterocycles bearing nitrogen, sulphur and thiazole moieties constitute the core structure of a number of biologically interesting compounds. Benzothiazole, a group of xenobiotic compounds containing a benzene ring fused with a thiazole ring, are used worldwide for a variety of therapeutic applications. Benzothiazole and their heterocyclic derivatives represent an important class of compounds possessing a wide spectrum of biological activities. The myriad spectrum of medicinal properties associated with benzothiazole related drugs has encouraged the medicinal chemists to synthesize a large number of novel therapeutic agents. Several analogues containing benzothiazole ring system exhibit significant antitumour, antimicrobial, antidiabetic, anti-inflammatory, anticonvulsant, antiviral, antioxidant, antitubercular, antimalarial, antiasthmatic, anthelmintic, photosensitizing, diuretic, analgesic and other activities. This article is an attempt to present the research work reported in recent scientific literat...