R
Ramesh A. Shivdasani
Researcher at Harvard University
Publications - 207
Citations - 25188
Ramesh A. Shivdasani is an academic researcher from Harvard University. The author has contributed to research in topics: Transcription factor & Cellular differentiation. The author has an hindex of 82, co-authored 202 publications receiving 22656 citations. Previous affiliations of Ramesh A. Shivdasani include University of Michigan & Albert Einstein College of Medicine.
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Journal ArticleDOI
Genomic analysis identifies association of Fusobacterium with colorectal carcinoma
Aleksandar Kostic,Dirk Gevers,Chandra Sekhar Pedamallu,Chandra Sekhar Pedamallu,Monia Michaud,Fujiko Duke,Fujiko Duke,Ashlee M. Earl,Akinyemi I. Ojesina,Akinyemi I. Ojesina,Joonil Jung,Adam J. Bass,Adam J. Bass,Josep Tabernero,José Baselga,Chen Liu,Ramesh A. Shivdasani,Shuji Ogino,Bruce W. Birren,Curtis Huttenhower,Curtis Huttenhower,Wendy S. Garrett,Wendy S. Garrett,Matthew Meyerson,Matthew Meyerson +24 more
TL;DR: The composition of the microbiota in colorectal carcinoma is characterized using whole genome sequences from nine tumor/normal pairs and Fusobacterium sequences were enriched in carcinomas, confirmed by quantitative PCR and 16S rDNA sequence analysis of 95 carcinoma/normal DNA pairs.
Journal ArticleDOI
Absence of blood formation in mice lacking the T-cell leukaemia oncoprotein tal-1/SCL.
TL;DR: It is shown by targeted gene disruption in mice that tal-1 is essential for embryonic blood formation in vivo and resembles loss of the erythroid transcription factor GATA-113,14 or the LIM protein rbtn215 .
Journal ArticleDOI
SOX2 is an amplified lineage-survival oncogene in lung and esophageal squamous cell carcinomas
Adam J. Bass,Adam J. Bass,Hideo Watanabe,Hideo Watanabe,Craig H. Mermel,Craig H. Mermel,Soyoung Yu,Sven Perner,Sven Perner,Roeland Verhaak,Roeland Verhaak,So Young Kim,Leslie Wardwell,Pablo Tamayo,Irit Gat-Viks,Alex H. Ramos,Alex H. Ramos,Michele S. Woo,Michele S. Woo,Barbara A. Weir,Barbara A. Weir,Gad Getz,Rameen Beroukhim,Rameen Beroukhim,Michael O'Kelly,Amit Dutt,Amit Dutt,Orit Rozenblatt-Rosen,Piotr Dziunycz,Justin Komisarof,Lucian R. Chirieac,Christopher J. LaFargue,Veit Scheble,Theresia Wilbertz,Changqing Ma,Shilpa Rao,Hiroshi Nakagawa,Douglas B. Stairs,Lin Lin,Thomas J. Giordano,Patrick L. Wagner,John D. Minna,Adi F. Gazdar,Chang-Qi Zhu,Marcia S. Brose,Ivan Cecconello,Ulysses Ribeiro,Suely Kazue Nagahashi Marie,Olav Dahl,Ramesh A. Shivdasani,Ming-Sound Tsao,Mark A. Rubin,Kwok K. Wong,Aviv Regev,William C. Hahn,William C. Hahn,David G. Beer,Anil K. Rustgi,Matthew Meyerson,Matthew Meyerson +59 more
TL;DR: A peak of genomic amplification on chromosome 3q26.33 found in squamous cell carcinomas of the lung and esophagus contains the transcription factor gene SOX2, which is necessary for normal esophageal squamous development, promotes differentiation and proliferation of basal tracheal cells and cooperates in induction of pluripotent stem cells.
Journal ArticleDOI
A lineage‐selective knockout establishes the critical role of transcription factor GATA‐1 in megakaryocyte growth and platelet development
Ramesh A. Shivdasani,Yuko Fujiwara,Yuko Fujiwara,Yuko Fujiwara,Michael A. McDevitt,Stuart H. Orkin +5 more
TL;DR: A critical role for GATA‐1 is revealed in megakaryocyte growth regulation and platelet biogenesis, and targeted mutation of cis‐elements can generate lineage‐specific knockout mice are illustrated.
Journal ArticleDOI
Transcription factor NF-E2 is required for platelet formation independent of the actions of thrombopoietin/MGDF in megakaryocyte development.
Ramesh A. Shivdasani,Margery Rosenblatt,Dorothea Zucker-Franklin,Carl W. Jackson,Pamela Hunt,Chris J.M Saris,Stuart H. Orkin +6 more
TL;DR: The authors showed that NF-E2 −/− mice lack circulating platelets and die of hemorrhage; their megakaryocytes show no cytoplasmic platelet formation.