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Author

Ramin Ghahremanzadeh

Bio: Ramin Ghahremanzadeh is an academic researcher from Avicenna Research Institute. The author has contributed to research in topics: Indoline & Condensation reaction. The author has an hindex of 24, co-authored 89 publications receiving 1796 citations. Previous affiliations of Ramin Ghahremanzadeh include Islamic Azad University & Shahid Beheshti University.


Papers
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Journal ArticleDOI
TL;DR: Triethylamine was found to be an efficient catalyst for the synthesis of 1H-pyrazolo[1,2-b]phthalazine-5,10-diones by one-pot reaction of phthalhydrazide, aromatic aldehydes, and malononitrile or ethyl cyanoacetate in ethanol under ultrasonic irradiation.

137 citations

Journal Article
TL;DR: The key characteristics of ADCs including tumor marker, antibody, cytotoxic payload, and linkage strategy are outlined with a focus on technical improvement and some future trends in the pipeline.
Abstract: The design of Antibody Drug Conjugates (ADCs) as efficient targeting agents for tumor cell is still in its infancy for clinical applications. This approach incorporates the antibody specificity and cell killing activity of chemically conjugated cytotoxic agents. Antibody in ADC structure acts as a targeting agent and a nanoscale carrier to deliver a therapeutic dose of cytotoxic cargo into desired tumor cells. Early ADCs encountered major obstacles including, low blood residency time, low penetration capacity to tumor microenvironment, low payload potency, immunogenicity, unusual off-target toxicity, drug resistance, and the lack of stable linkage in blood circulation. Although extensive studies have been conducted to overcome these issues, the ADCs based therapies are still far from having high-efficient clinical outcomes. This review outlines the key characteristics of ADCs including tumor marker, antibody, cytotoxic payload, and linkage strategy with a focus on technical improvement and some future trends in the pipeline.

128 citations

Journal ArticleDOI
TL;DR: A one-pot method for the efficient and simple synthesis of the novel spiro[indoline-pyrazolo[4',3':5,6]pyrido[2,3-d]pyrimidine]trione derivatives by a three-component condensation reaction of barbituric acids, 1H-pyazol-5-amines and isatins in aqueous media is reported.
Abstract: A one-pot method for the efficient and simple synthesis of the novel spiro[indoline-pyrazolo[4′,3′:5,6]pyrido[2,3-d]pyrimidine]trione derivatives by a three-component condensation reaction of barbituric acids, 1H-pyrazol-5-amines and isatins in aqueous media is reported.

119 citations

Journal ArticleDOI
TL;DR: An efficient one-pot synthesis of novel 8,9-dihydrospiro[chromeno[2,3-d]pyrimidine-5,3'-indoline]-2,2',4,6(1H,3H,7H)-tetraone derivatives by a three-component condensation reaction of barbituric acids, isatins and cyclohexane-1,3
Abstract: An efficient one-pot synthesis of novel 8,9-dihydrospiro[chromeno[2,3-d]pyrimidine-5,3′-indoline]-2,2′,4,6(1H,3H,7H)-tetraone derivatives by a three-component condensation reaction of barbituric acids, isatins and cyclohexane-1,3-diones in refluxing water in the presence of p-TSA for 10 h is reported. Two cyclohexane-1,3-diones, three barbituric acids, and eight substituted isatins were chosen for the library validation. Reaction of 5,5-dimethyl-cyclohexane-1,3-dione and acenaphthylene-1,2-dione with barbituric acids resulted in the formation of spiro[acenaphthylene-1,5′-chromeno[2,3-d]pyrimidine] derivatives.

98 citations

Journal ArticleDOI
TL;DR: A green reaction of isatins, active cyanomethanes, and cyclic 1,3-dicarbonyl derivatives for the efficient and simple one-pot three-component synthesis of spirooxindole fused heterocycles in refluxing water by use of magnetically recoverable and reusable catalyst is reported.
Abstract: A green reaction of isatins, active cyanomethanes, and cyclic 1,3-dicarbonyl derivatives for the efficient and simple one-pot three-component synthesis of spirooxindole fused heterocycles in refluxing water by use of magnetically recoverable and reusable catalyst is reported. The features of this procedure are, the use of magnetically recoverable and reusable catalyst, mild reaction conditions, high to excellent product yields, operational simplicity, and easy workup procedures. Most importantly of all, easy magnetic separation of the catalyst eliminates the requirement of catalyst filtration after completion of the reaction. Furthermore, the catalyst remained highly active even after 5 repeated uses.

94 citations


Cited by
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Journal ArticleDOI
TL;DR: A critical appraisal of different synthetic approaches to Cu and Cu-based nanoparticles and copper nanoparticles immobilized into or supported on various support materials (SiO2, magnetic support materials, etc.), along with their applications in catalysis.
Abstract: The applications of copper (Cu) and Cu-based nanoparticles, which are based on the earth-abundant and inexpensive copper metal, have generated a great deal of interest in recent years, especially in the field of catalysis. The possible modification of the chemical and physical properties of these nanoparticles using different synthetic strategies and conditions and/or via postsynthetic chemical treatments has been largely responsible for the rapid growth of interest in these nanomaterials and their applications in catalysis. In addition, the design and development of novel support and/or multimetallic systems (e.g., alloys, etc.) has also made significant contributions to the field. In this comprehensive review, we report different synthetic approaches to Cu and Cu-based nanoparticles (metallic copper, copper oxides, and hybrid copper nanostructures) and copper nanoparticles immobilized into or supported on various support materials (SiO2, magnetic support materials, etc.), along with their applications i...

1,823 citations

Journal ArticleDOI
TL;DR: In this paper, a review summarizes recent results of multicomponent reactions obtained in unconventional media including water, ionic liquids, polyethylene glycol and bio-based solvents.

498 citations

01 Sep 2011
TL;DR: Incorporating gold nanowires into scaffolds used to create heart patches can improve electrical communication between cells and enhance the growth of tissues as discussed by the authors, which can improve the electrical communication among cells.
Abstract: Incorporating gold nanowires into scaffolds used to create heart patches can improve electrical communication between cells and enhance the growth of tissues.

482 citations