R
Ramiro Garzon
Researcher at Ohio State University
Publications - 193
Citations - 21138
Ramiro Garzon is an academic researcher from Ohio State University. The author has contributed to research in topics: Myeloid leukemia & Leukemia. The author has an hindex of 55, co-authored 185 publications receiving 19462 citations. Previous affiliations of Ramiro Garzon include Case Western Reserve University & City of Hope National Medical Center.
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Journal ArticleDOI
MicroRNA-29 family reverts aberrant methylation in lung cancer by targeting DNA methyltransferases 3A and 3B.
Muller Fabbri,Ramiro Garzon,Amelia Cimmino,Amelia Cimmino,Zhongfa Liu,Nicola Zanesi,Elisa Callegari,Shujun Liu,Hansjuerg Alder,Stefan Costinean,Cecilia Fernandez-Cymering,Stefano Volinia,Gulnur Guler,Carl Morrison,Kenneth K. Chan,Guido Marcucci,George A. Calin,Kay Huebner,Carlo M. Croce +18 more
TL;DR: The enforced expression of miR-29s in lung cancer cell lines restores normal patterns of DNA methylation, induces reexpression of methylation-silenced tumor suppressor genes, and inhibits tumorigenicity in vitro and in vivo.
Journal ArticleDOI
MicroRNAs in Cancer.
TL;DR: This review briefly describes miRNA biogenesis and discusses how miRNAs can act as oncogenes and tumor suppressors and the role of miRNAAs in the diagnosis, prognosis, and treatment of cancer.
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Targeting microRNAs in cancer: rationale, strategies and challenges.
TL;DR: The role of miRNAAs in tumorigenesis is described and the rationale, the strategies and the challenges for the therapeutic targeting of miRNAs in cancer are critically discussed.
Journal ArticleDOI
A MicroRNA Signature of Hypoxia
Ritu Kulshreshtha,Manuela Ferracin,Sylwia E. Wojcik,Ramiro Garzon,Hansjuerg Alder,Francisco J. Agosto-Perez,Ramana V. Davuluri,Chang Gong Liu,Carlo M. Croce,Massimo Negrini,George A. Calin,Mircea Ivan +11 more
TL;DR: A functional link between hypoxia, a well-documented tumor microenvironment factor, and microRNA expression is demonstrated for the first time and selected microRNAs decrease proapoptotic signaling in a hypoxic environment, suggesting an impact of these transcripts on tumor formation.
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MicroRNA expression and function in cancer
TL;DR: Large high-throughput studies in patients revealed that miRNA profiling have the potential to classify tumors with high accuracy and predict outcome and the role of miRNAs in the pathogenesis of cancer is examined.