R
Randall J. Olsen
Researcher at Houston Methodist Hospital
Publications - 194
Citations - 7246
Randall J. Olsen is an academic researcher from Houston Methodist Hospital. The author has contributed to research in topics: Virulence & Streptococcus pyogenes. The author has an hindex of 41, co-authored 178 publications receiving 5530 citations. Previous affiliations of Randall J. Olsen include Cornell University & Texas A&M Health Science Center College of Medicine.
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Journal ArticleDOI
Integrating Rapid Pathogen Identification and Antimicrobial Stewardship Significantly Decreases Hospital Costs
Katherine K. Perez,Randall J. Olsen,William L. Musick,Patricia L. Cernoch,James R. Davis,Geoffrey Land,Leif E. Peterson,James M. Musser +7 more
TL;DR: In this article, an evidence-based intervention that integrated matrix-assisted laser desorption and ionization time-of-flight mass spectrometry, rapid antimicrobial susceptibility testing, and near-real-time antimicrobial stewardship practices was implemented.
Journal ArticleDOI
Molecular dissection of the evolution of carbapenem-resistant multilocus sequence type 258 Klebsiella pneumoniae
Frank R. DeLeo,Liang Chen,Stephen F. Porcella,Craig Martens,Scott D. Kobayashi,Adeline R. Porter,Kalyan D. Chavda,Michael R. Jacobs,Barun Mathema,Randall J. Olsen,Robert A. Bonomo,Robert A. Bonomo,James M. Musser,Barry N. Kreiswirth +13 more
TL;DR: In this paper, the authors found that carbapenem-resistant Klebsiella pneumoniae is a single genetic clone that has disseminated worldwide, which disproved the single-clone hypothesis.
Journal ArticleDOI
Integrating rapid diagnostics and antimicrobial stewardship improves outcomes in patients with antibiotic- resistant Gram-negative bacteremia
Katherine K. Perez,Randall J. Olsen,William L. Musick,Patricia L. Cernoch,James R. Davis,Leif E. Peterson,James M. Musser +6 more
TL;DR: Integration of rapid identification and susceptibility techniques with antimicrobial stewardship resulted in significant improvements in clinical and financial outcomes for patients with bloodstream infections caused by antibiotic-resistant Gram-negatives.
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Evolutionary pathway to increased virulence and epidemic group A Streptococcus disease derived from 3,615 genome sequences.
Waleed Nasser,Stephen B. Beres,Randall J. Olsen,Melissa A. Dean,Kelsey A. Rice,S. Wesley Long,Karl G. Kristinsson,Magnus Gottfredsson,Jaana Vuopio,Kati Räisänen,Dominique A. Caugant,Martin Steinbakk,Donald E. Low,Allison McGeer,Jessica Darenberg,Birgitta Henriques-Normark,Birgitta Henriques-Normark,Chris A. Van Beneden,Steen Hoffmann,James M. Musser +19 more
TL;DR: Analysis of 3,615 genome sequences permitted us to delineate the nature and timing of molecular events that contributed to an ongoing global human epidemic of infections caused by group A Streptococcus, the “flesh-eating” pathogen, and resolve a decades-long controversy about the type and sequence of genomic alterations that produced this explosive epidemic.
Journal ArticleDOI
Treatment of Coronavirus Disease 2019 (COVID-19) Patients with Convalescent Plasma.
Eric Salazar,Katherine K. Perez,Madiha Ashraf,Jian Chen,Brian Castillo,Paul A. Christensen,Taryn A Eubank,David W. Bernard,Todd N. Eagar,S. Wesley Long,Sishir Subedi,Randall J. Olsen,Christopher Leveque,Mary R. Schwartz,Monisha Dey,Cheryl Chavez-East,John Rogers,Ahmed Shehabeldin,David Joseph,Guy Williams,Karen D. Thomas,Faisal Masud,Christina Talley,Katharine G. Dlouhy,Bevin Valdez Lopez,Curt Hampton,Jason J. Lavinder,Jimmy Gollihar,Andre C. Maranhao,Gregory C. Ippolito,Matthew Ojeda Saavedra,Concepcion C. Cantu,Prasanti Yerramilli,Layne Pruitt,James M. Musser,James M. Musser +35 more
TL;DR: Administration of convalescent plasma is a safe treatment option for those with severe COVID-19 disease, and whole genome sequencing data did not identify a strain genotype-disease severity correlation.