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Rangaswamy

Bio: Rangaswamy is an academic researcher from University of Mysore. The author has contributed to research in topics: Zinc. The author has an hindex of 1, co-authored 1 publications receiving 46 citations.
Topics: Zinc

Papers
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Journal ArticleDOI
TL;DR: In this article, anisaldehyde thiosemicarbazone (PAT) has been used to isolate the complex compounds of the general formula [M(PAT),X 2 ]H 2 O where M(II) = Zn, Hg, Cd and Cu, and X = Cl or 1 2 SO 4.

46 citations


Cited by
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Journal ArticleDOI
TL;DR: In this paper, the authors discuss the biological importance of copper thiosemicarbazone complexes and their applications in the field of chemical engineering, such as chemical synthesis, chemical engineering and electrical engineering.

765 citations

Journal ArticleDOI
TL;DR: The testing of the cytotoxic activity of these compounds against several human and murine cell lines sensitive and resistant to cisplatin (cis-DDP) suggests that compounds 2, 3, and 4 may be endowed with important anticancer properties since they elicit IC50 values in the microM range.
Abstract: The reaction of p-isopropylbenzaldehyde thiosemicarbazone [p-is.TSCN], 1, with palladium(II) acetate and potassium tetrachloroplatinate yielded two tetrameric orthopalladated isomers, [Pd(p-is.TSCN)]4 (complexes 2 and 3), and the platinum analogue [Pt(p-is.TSCN)]4 (complex 4), respectively. All of these complexes contain the thiosemicarbazone bonded as a terdentate ligand to the metallic atom, through the thiol sulfur, the azomethinic nitrogen and the ortho carbon of the p-isopropylphenyl ring to which the imine group is attached to as deduced from the study of the IR, NMR, and XRD spectra of complexes 2 and 4. Complexes 2 and 4 crystallize in the centrosymmetric monoclinic space group C2/c, with Z = 8. Unit cell parameters for complex 2 are as follows: a = 25.742(5) A, b = 19.560(4) A, c = 24.199(5) A, beta = 101.70(3)o. Unit cell parameters for complex 4 are as follows: a = 25.8728(19) A, b = 19. 5053(14) A, c = 24.0899(16) A, beta = 101.305(2)o. As can be deduced from the NMR study, the palladated isomers 2 and 3 interconvert in DMSO which may be a consequence of the existence in both complexes of a flexible eight-membered ring with alternating Pd-S atoms. The testing of the cytotoxic activity of these compounds against several human and murine cell lines sensitive and resistant to cisplatin (cis-DDP) suggests that compounds 2, 3, and 4 may be endowed with important anticancer properties since they elicit IC50 values in the microM range as does the clinically used drug cis-DDP, and, moreover, they display cytotoxic activity in tumor lines resistant to cis-DDP. The analysis of the interaction of these novel tetrameric cyclometalated compounds with DNA suggests that they form DNA interhelical cross-links.

220 citations

Journal ArticleDOI
TL;DR: In this article, a five-coordinate structure for the NNS tridentate chelating agent and a distorted octahedral structure for a bis-ligand NNS thiosemicarbazone ligand were derived.

75 citations

Journal ArticleDOI
TL;DR: In this paper, the structure of the benzimidazol-2-ylmethyl-phenylamine (L 2 ) and its Pd-II and Pt-II complexes were elucidated using a variety of physico-chemical techniques, including geometry optimization, vibrational assignments, charge distribution and molecular orbital description HOMO and LUMO.

69 citations

Journal ArticleDOI
TL;DR: The antibacterial and antifungal activities of the isolated compounds were studied using a wide spectrum of bacterial and fungal strains.

68 citations