J. Appl. Cryst.の発刊に際して

IT may occasion some surprise to those men of science who are ill-acquainted with India, and who so frequently express the view that Governments are unappreciative of the importance of science to learn that as far back as 1886 the Government of India arranged for Dr. George (later Sir George) Watt, professor of botany in the Presidency College, Calcutta, to prepare a "Dictionary of the Economic Products of India". The six volumes of this standard work were published during the years 1889-99. In 1908 Sir George Watt published a condensed version, "The Commercial Products of India". Whatever the defects of these 'dictionaries', they have been of inestimable value to all interested in Indian natural products. The Wealth of India A Dictionary of Indian Raw Materials and Industrial Products. Raw Materials, Vol. 1. Pp. xxvii+254+39 plates. 15 rupees ; 24s. Industrial Products, Part 1. Pp. xii+182+8 plates. 8 rupees ; 12s. (New Delhi : Council of Scientific and Industrial Research, 1948.)

The Wealth of India

The Journal of Physical Chemistry Letters

Purpose: Combretastatin A4 (CA4) phosphate (CA4P) inhibits microtubule polymerization and is toxic to proliferating endothelial cells in vitro. It causes reversible vascular shutdown in established tumors in vivo, consistent with an antivascular mechanism of action. The present study investigated escalating doses of CA4P administered intravenously to patients with advanced cancer. Patients and Methods: Patients with solid malignancies and good performance status received CA4P as a 10-minute infusion daily for 5 days repeated every 3 weeks. Pharmacokinetic sampling was performed during cycle 1. Patients receiving ≥ 52 mg/m 2 /d had serial dynamic contrast-enhanced magnetic resonance imaging (DCE-MRI) studies to measure changes in tumor perfusion with CA4P treatment. Results: Thirty-seven patients received 133 treatment cycles. CA4P dose levels ranged from 6 mg/m 2 to 75 mg/m 2 daily. Severe pain at sites of known tumor was dose limiting at 75 mg/m 2 . Dose-limiting cardiopulmonary toxicity (syncope and dyspnea or hypoxia) was noted as well in two patients treated at 75 mg/m 2 . Other toxicities included hypotension, ataxia, dyspnea, nausea or vomiting, headache, and transient sensory neuropathy. Plasma CA4P and CA4 area under the concentration-time curve and maximal concentration values increased linearly with dose. Tumor perfusion, as measured by the first-order rate constant of gadolinium plasma to tissue transfer during DCE-MRI studies, was found to decrease in eight of 10 patients. Relationships were also demonstrated between perfusion changes and pharmacokinetic indices. A partial response was observed in a patient with metastatic soft tissue sarcoma, and 14 patients exhibited disease stability for a minimum of two cycles. Conclusion: Doses of CA4P on a daily times five schedule of 52 to 65 mg/m 2 were reasonably well-tolerated. The 52 mg/m 2 dose is recommended for further study based on cumulative phase I experience with CA4P. Antitumor efficacy was observed, and the use of DCE-MRI provided a valuable noninvasive measure of the vascular effects of CA4P treatment.

Phase I trial of the antivascular agent Combretastatin A4 phosphate on a 5-day schedule to patients with cancer: Magnetic resonance imaging evidence for altered tumor blood flow

https://espace.library.uq.edu.au/view/UQ:08f48a6/UQ08f48a6_OA.pdf

Degradation and stabilization of polyurethane elastomers

Biological transformations of steroidal compounds: a review.

Among heavy metals, lead and copper pose a significant threat to the due to their toxicity, incremental accumulation in the food chain and persistence in the ecosystem. Lead and copper are introduced into water from various industries and other human activities. Present study was aimed to remove lead and copper from aqueous media using Fumaria indica biomass as a function of metal ions initial concentration. Both metal removal was investigated in single and binary system. For comparison isotherm models i.e., Langmuir and Freundlich were applied on experimental adsorption data. Results showed that the copper behavior was different in single and binary metal system, whereas lead adsorption remained the same in both single and binary metal systems. The Freundlich isotherm model fitted well to the adsorption data of both single and binary metal system. The thermodynamic parameters i.e., ∆G 0 , was measured to get insight into adsorption phenomenon and negative value of ∆G 0

Adsorption of copper and lead in single and binary metal system onto Fumaria indica biomass

Tuning the optoelectronic properties of Subphthalocyanine (SubPc) derivatives for photovoltaic applications

Synthesis and characterization of chitosan modified polyurethane bio-nanocomposites with biomedical potential.

Designing benzothiadiazole based non-fullerene acceptors with high open circuit voltage and higher LUMO level to increase the efficiency of organic solar cells

Rasheed Ahmad Khera

Papers

Biological transformations of steroidal compounds: a review.

Adsorption of copper and lead in single and binary metal system onto Fumaria indica biomass

Tuning the optoelectronic properties of Subphthalocyanine (SubPc) derivatives for photovoltaic applications

Synthesis and characterization of chitosan modified polyurethane bio-nanocomposites with biomedical potential.

Designing benzothiadiazole based non-fullerene acceptors with high open circuit voltage and higher LUMO level to increase the efficiency of organic solar cells