Rashid Z. Musin

Bio: Rashid Z. Musin is an academic researcher from Russian Academy of Sciences. The author has contributed to research in topics: Hexafluoroacetone & Phosphorus trichloride. The author has an hindex of 11, co-authored 164 publications receiving 668 citations. Previous affiliations of Rashid Z. Musin include Kazan State Technological University.

Facile Synthesis of 1,1′-Dialkylisoindigosthrough Deoxygenation Reaction of Isatins and Tris(diethylamino)phosphine

Abstract: A convenient one-step synthesis of symmetrical 1,1’-dialkyl derivatives of isoindigo is described Key words carbenes, deoxygenation, heterocycles, regioselectivity, phosphorus In the last years, isoindigo [1H,1’H-bis(indolin-3-yliden)-2,2’-dione] and especially it’s N- and N,N’-derivatives attract great attention not only as dyes, but as substances which possess a specific biological activity (anti-leukemia, antiproliferative, anti-inflammatory etc) 1-4 Thus, 1-(β-D-glucopyranosyl)-isoindigo was found to be an anti-leukemia drug 2-4 It has to be noted that the synthesis of 1-substituted isoindigo often is a multistep procedure The best approach to the synthesis of isoindigo derivatives seems to be the dimerization of ketocarbenes generated from isatin derivatives It has been assumed 5,6 that mixture of 3-(triphenylphosphoranyliden)-2,3-dihydro-1H-indol-2-one and isoindigo is formed with moderate yield by the reaction of triphenylphosphine with isatin and 1-methylisatin through intermediate carbene formation However, generation of carbenes from heterocyclic -diketones under the action of trivalent phosphorus deriv-atives has been insufficiently studied

Synthesis and anti-tuberculous activity of diesters based on isosteviol and dicarboxylic acids

Abstract: Diesters based on isosteviol and dicarboxylic acids were synthesized and tested for antituberculous activity. Isosteviol and some of its derivatives exhibit appreciable tuberculostatic properties in vitro, the activity being dependent on the length of the polymethylene spacer connecting two ent-beyeran fragments. The mechanism of the antituberculous action of isosteviol derivatives are discussed.

New synthesis of diterpenoid (16S)-dihydrosteviol

Abstract: A new procedure has been developed for the synthesis of diterpenoid (16S)-dihydrosteviol [(16S)-13-hydroxy-ent-kauran-19-oic acid] by acid hydrolysis (0.7% hydrochloric acid) of SWETA food sweetener and subsequent reduction of the resulting mixture of caurenoids with hydrazine hydrate over Raney nickel. The molecular geometry of (16S)-dihydrosteviol, as well as of Δ15-steviol (13-hydroxy-ent-kaur-15-en-19-oic acid), was determined for the first time by X-ray analysis.

Frustrated Lewis pairs: metal-free hydrogen activation and more.

Abstract: Sterically encumbered Lewis acid and Lewis base combinations do not undergo the ubiquitous neutralization reaction to form "classical" Lewis acid/Lewis base adducts. Rather, both the unquenched Lewis acidity and basicity of such sterically "frustrated Lewis pairs (FLPs)" is available to carry out unusual reactions. Typical examples of frustrated Lewis pairs are inter- or intramolecular combinations of bulky phosphines or amines with strongly electrophilic RB(C(6)F(5))(2) components. Many examples of such frustrated Lewis pairs are able to cleave dihydrogen heterolytically. The resulting H(+)/H(-) pairs (stabilized for example, in the form of the respective phosphonium cation/hydridoborate anion salts) serve as active metal-free catalysts for the hydrogenation of, for example, bulky imines, enamines, or enol ethers. Frustrated Lewis pairs also react with alkenes, aldehydes, and a variety of other small molecules, including carbon dioxide, in cooperative three-component reactions, offering new strategies for synthetic chemistry.

25th Anniversary Article: Isoindigo-Based Polymers and Small Molecules for Bulk Heterojunction Solar Cells and Field Effect Transistors

Abstract: Driven by the potential advantages and promising applications of organic solar cells, donor-acceptor (D-A) polymers have been intensively investigated in the past years. One of the strong electron-withdrawing groups that were widely used as acceptors for the construction of D-A polymers for applications in polymer solar cells and FETs is isoindigo. The isoindigo-based polymer solar cells have reached efficiencies up to approximate to 7% and hole mobilities as high as 3.62 cm(2) V-1 s(-1) have been realized by FETs based on isoindigo polymers. Over one hundred isoindigo-based small molecules and polymers have been developed in only three years. This review is an attempt to summarize the structures and properties of the isoindigo-based polymers and small molecules that have been reported in the literature since their inception in 2010. Focus has been given only to the syntheses and device performances of those polymers and small molecules that were designed for use in solar cells and FETs. Attempt has been made to deduce structure-property relationships that would guide the design of isoindigo-based materials. It is expected that this review will present useful guidelines for the design of efficient isoindigo-based materials for applications in solar cells and FETs.