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Rasilingam Duraisami

Bio: Rasilingam Duraisami is an academic researcher. The author has contributed to research in topics: Carbon tetrachloride & Vitamin E. The author has an hindex of 3, co-authored 4 publications receiving 80 citations.

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01 Jan 2008
TL;DR: In this article, the authors evaluated the hepatoprotective activity of Camellia sinensis leaves and its possible mechanism of action and concluded that Camellias sinensis 100 and 200mg/kg results in significant reduction in 19 serum hepatic enzymes and liver lipid peroxide which were increased by carbon tetrachloride.
Abstract: The present study appraised the hepatoprotective activity of aqueous extract of Camellia sinensis leaves 10 and its possible mechanism of action. Liver damage was induced by intraperitoneal administration of car11 bon tetrachloride/olive oil (50 % v/v, 0.5 ml/kg ) in male Wistar rats (150-220g) once daily for 7 days and 12 the extent of damage was studied by assessing biochemical parameters such as alanine amino trans13 ferase (ALT), aspartate amino transferase (AST), alkaline phosphatase (ALP), total protein and albumin 14 in serum and concentrations of lipid peroxides (LPO), glutathione (GSH), catalase (CAT) and superoxide 15 dismutase (SOD) in liver. The aqueous extract of Camellia sinensis (100 mg and 200 mg/Kg) were ad16 ministered orally to the animals with hepatotoxicity induced by carbon tetrachloride and its effects on bio17 chemical parameters were compared with those in animals treated with vitamin E (100 mg/Kg). Histopa18 thological studies were also done. Camellia sinensis 100 and 200mg/kg results in significant reduction in 19 serum hepatic enzymes and liver lipid peroxide which were increased by carbon tetrachloride. There was 20 significant increase in serum total protein, albumin and liver GSH, SOD and CAT when compared to 21 those in rats treated by carbon tetrachloride. The antioxidant activity of Camellia sinensis (100 and 22 200mg/Kg) were comparable with the effects of vitamin E (100mg/Kg). Histopathological changes (con23 gestion of central vein, centrilobular necrosis and sinusoidal congestion) induced by carbon tetrachloride 24 were reduced to a moderate extent in Camellia-sinensis-treated rats. Taking together, Camellia sinensis 25 protectes the liver from carbon-tetrachloride-induced damage. Probable mechanism of its action is its 26 anti-oxidant property. 27

55 citations

Journal ArticleDOI
TL;DR: It is concluded that the aqueous extract of Trianthema decandra roots has protected the liver from carbon tetrachloride-induced damage.
Abstract: Th e present study appraised the hepatoprotective activity of aqueous extract of Trianthema decandra roots against carbon tetrachlorideinduced liver damage. Liver damage was induced by intraperitoneal administration of an equal mixture of carbon tetrachloride and olive oil (50% v/v, 0.5 ml/kg) in male Wistar rats (150-220 g) once daily for 7 days and the extent of damage was studied by assessing the biochemical parameters such as alanine amino transferase (ALT), aspartate amino transferase (AST), alkaline phosphatase (ALP), total protein and albumin in serum. Th e aqueous extract of Trianthema decandra roots (50 mg, 100 mg and 200 mg/kg) were orally administered to the animals with hepatotoxicity induced by carbon tetrachloride and its eff ects on biochemical parameters were compared with Silymarin (25 mg/kg) treated animals. Trianthema decandra (100 and 200 mg/kg) results in a signifi cant reduction in serum hepatic enzymes when compared to rats treated with carbon tetrachloride alone. Th ere was a signifi cant increase in the serum total protein and albumin when compared to rats treated with carbon tetrachloride alone. Th e results concludes that the aqueous extract of Trianthema decandra roots (100 and 200 mg/kg) has protected the liver from carbon tetrachloride-induced damage. Key words: Carbon tetrachloride, hepatoprotective and silymarin, Trianthema decandra

15 citations

Journal Article
TL;DR: In this paper, the authors evaluated the hepatoprotective activity of Camellia sinensis leaves and its possible mechanism of action against carbon-tetrachloride-induced liver damage.
Abstract: The present study appraised the hepatoprotective activity of aqueous extract of Camellia sinensis leaves and its possible mechanism of action against carbon-tetrachloride-induced liver damage. Liver damage was induced by intraperitoneal administration of equal mixture of carbon tetrachloride and olive oil (50 % v/v, 0.5 ml/kg ) in male Wistar rats (150-220g) once daily for 7 days and the extent of damage was studied by assessing biochemical parameters such as alanine amino transferase (ALT), aspartate amino transferase (AST), alkaline phosphatase (ALP), total protein and albumin in serum and concentrations of lipid peroxides (LPO), glutathione (GSH), catalase (CAT) and superoxide dismutase (SOD) in liver . The aqueous extract of Camellia sinensis (100 mg and 200 mg/Kg) were administered orally to the animals with hepatotoxicity induced by carbon tetrachloride and its effects on biochemical parameters were compared with Vitamin E (100 mg/Kg) treated animals. Histopathological studies of the experimental animal were also done. Camellia sinensis 100 and 200mg/kg results in significant reduction in serum hepatic enzymes and liver lipid peroxide which were increased by carbon tetrachloride. There was significant increase in serum total protein, albumin and liver GSH, SOD and CAT when compared to those in rats treated by carbon tetrachloride . The antioxidant activity of Camellia sinensis (100 and 200mg/Kg) were comparable with the effects of Vitamin E (100mg/Kg). Histopathological changes (congestion of central vein, centrilobular necrosis and sinusoidal congestion) induced by carbon tetrachloride were prevented to a moderate extent in Camellia-sinensis -treated rats. Taking together, Camellia sinensis protectes the liver from carbon-tetrachloride-induced damage. Probable mechanism of its action may be due to its anti-oxidant property .

13 citations

01 Jan 2008
TL;DR: The present study appraised the hepatoprotective activity of aqueous extract of Camellia sinensis and its possible mechanism of action and its effects on animals with hepatotoxicity induced by carbon tetrachloride.
Abstract: The present study appraised the hepatoprotective activity of aqueous extract of Camellia sinensisleaves and its possible mechanism of action.Liver damage was induced byintraperitoneal administration ofcarbon tetrachloride/olive oil (50 % v/v, 0.5 ml/kg ) in male Wistar rats (150 -220g) once daily for 7 days and the extent of damage was studied by assessing biochemical pa rameters such as alanine amino tran sferase (ALT), aspartate amino transferase (AST), alkaline phosphatase (ALP), total protein and albumin in serum and concentrations of lipid peroxides (LPO), glutathione (GSH), catalase (CAT) and superoxide dismutase (SOD) in liver .The aqueous extract ofCamellia sinensis(100mg and 200 mg/Kg ) were administered orally to the animals with hepatotoxicity induced by carbon tetrachloride and its effects on bi o

3 citations


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Journal ArticleDOI
25 Jun 2013-Ulcers
TL;DR: Current in vivo animal models of ulcers and the pathophysiological mechanisms underlying their induction, their limitations, as well as the challenges associated with their use have been discussed.
Abstract: Peptic ulcer is among the most serious gastrointestinal diseases in the world. Several orthodox drugs are employed for the treatment of the disease. Although these drugs are effective, they produce many adverse effects thus limiting their use. In recent years, there has been a growing interest in alternative therapies, especially those from plants due to their perceived relative lower side effects, ease of accessibility, and affordability. Plant medicines with ethnomedicinal use in peptic ulcer management need to be screened for their effectiveness and possible isolation of lead compounds. This requires use of appropriate animal models of various ulcers. The limited number of antiulcer models for drug development against gastric and duodenal ulcer studies has hindered the progress of targeted therapy in this field. It is, therefore, necessary to review the literature on experimental models used to screen agents with potential antigastroduodenal ulcer activity and explain their biochemical basis in order to facilitate their use in the development of new preventive and curative antiulcer drugs. Clinical trials can then be carried out on agents/drugs that show promise. In this paper, current in vivo animal models of ulcers and the pathophysiological mechanisms underlying their induction, their limitations, as well as the challenges associated with their use have been discussed.

142 citations

Journal ArticleDOI
TL;DR: A thorough examination of data showing controversial effects induced by striatal 5-HT on dopaminergic activity suggests that the endogenous 5- HT system exerts multiple and subtle influences on DA-mediated behaviors.
Abstract: The influences of the serotonergic system on dopamine (DA) neuron activity have received considerable attention during the last three decades due to the real opportunity to improve disorders related to central DA neuron dysfunctions such as Parkinson’s disease, schizophrenia, or drug abuse with serotonergic drugs. Numerous biochemical and behavioral data indicate that serotonin (5-HT) affects dopaminergic terminal function in the striatum. The authors propose a thorough examination of data showing controversial effects induced by striatal 5-HT on dopaminergic activity. Inhibitory and excitatory effects of exogenous 5-HT have been reported on DA release and synthesis, involving various striatal 5-HT receptors. 5-HT also promotes an efflux of DA through reversal of the direction of DA transport. By analogy with the mechanism of action described for amphetamine, the consequences of 5-HT entering DA terminals might explain both the excitatory and inhibitory effects of 5-HT on presynaptic DA terminal activity, but the physiological relevance of this mechanism is far from clear. The recent data suggest that the endogenous 5-HT system affects striatal DA release in a state-dependent manner associated with the conditional involvement of various 5-HT receptors such as 5-HT2A, 5-HT2C, 5-HT3, and 5-HT4 receptors. Methodological and pharmacological issues have prevented a comprehensive overview of the influence of 5-HT on striatal DA activity. The distribution of striatal 5-HT receptors and their restricted influence on DA neuron activity suggest that the endogenous 5-HT system exerts multiple and subtle influences on DA-mediated behaviors.

102 citations

Journal ArticleDOI
TL;DR: Calendula inhibited HGF-mediated collagen degradation and MMP-2 activity more than the same correlated concentration of pure quercetin, which may be attributed to additional components in Calendula other than quercETin.

101 citations

Journal ArticleDOI
TL;DR: It is concluded that basil aqueous extract via antioxidant and possibly α-glucosidase and α-amylase inhibiting activities, offered positive benefits to control diabetes.
Abstract: The present study investigated the in vitro hypoglycemic activity of basil (Ocimum basilicum) aqueous extract. Preliminary phytochemical screening of the extract revealed the presence of reducing s...

95 citations

Journal ArticleDOI
TL;DR: The extract decreased intestinal transit time by attenuating the spontaneous contractions of the intestine, thus the study provided a scientific basis for the use of Annona senegalensis stem bark extract in the treatment of diarrhoea.

91 citations