R
Rasmus Kristoffer Pedersen
Researcher at Roskilde University
Publications - 19
Citations - 109
Rasmus Kristoffer Pedersen is an academic researcher from Roskilde University. The author has contributed to research in topics: Medicine & Internal medicine. The author has an hindex of 4, co-authored 12 publications receiving 57 citations.
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Journal ArticleDOI
Mathematical modelling as a proof of concept for MPNs as a human inflammation model for cancer development.
Morten Andersen,Zamra Sajid,Rasmus Kristoffer Pedersen,Johanne Gudmand-Hoeyer,Christina Ellervik,Vibe Skov,Lasse Kjær,Niels Pallisgaard,Torben A Kruse,Mads Thomassen,Jesper T. Troelsen,Hans Carl Hasselbalch,Johnny T. Ottesen +12 more
TL;DR: Using mathematical modeling, this work adds further proof to the concept that chronic inflammation may be both a trigger of clonal evolution and an important driving force for MPN disease progression.
Journal ArticleDOI
Data-driven analysis of JAK2V617F kinetics during interferon-alpha2 treatment of patients with polycythemia vera and related neoplasms.
Rasmus Kristoffer Pedersen,Morten Andersen,Trine Alma Knudsen,Zamra Sajid,Johanne Gudmand-Hoeyer,Marc J. B. Dam,Vibe Skov,Lasse Kjær,Christina Ellervik,Thomas Stauffer Larsen,Dennis Lund Hansen,Niels Pallisgaard,Hans Carl Hasselbalch,Johnny T. Ottesen +13 more
TL;DR: Novel information is provided regarding the JAK2V617F kinetics during IFN‐treatment, arguing for early intervention in patients with essential thrombocythemia and polycythemia vera.
Journal ArticleDOI
Bridging blood cancers and inflammation: The reduced Cancitis model
Johnny T. Ottesen,Rasmus Kristoffer Pedersen,Zamra Sajid,Johanne Gudmand-Hoeyer,Katrine O. Bangsgaard,Vibe Skov,Lasse Kjær,Trine Alma Knudsen,Niels Pallisgaard,Hans Carl Hasselbalch,Morten Andersen +10 more
TL;DR: It following that inflammation, affected by the exogenous inflammatory stimulation, may determine the onset and development of blood cancers, it follows that inflammation may trigger and drive blood cancers.
Journal ArticleDOI
Mathematical modelling of the hematopoietic stem cell-niche system: Clonal dominance based on stem cell fitness.
TL;DR: In this paper, a mechanism-based mathematical model of HSC dynamics within the bone-marrow microenvironment is proposed and analyzed based on the central hypothesis that HSC self-renewal depends on the stem cell niche.
Journal ArticleDOI
Mathematical Modeling of MPNs Offers Understanding and Decision Support for Personalized Treatment
Johnny T. Ottesen,Rasmus Kristoffer Pedersen,Marc John Bordier Dam,Trine Alma Knudsen,Vibe Skov,Lasse Kjær,Morten Andersen +6 more
TL;DR: In this paper, the effect of the treatment of myeloproliferative neoplasms (MPNs) with interferon-α2 on disease progression was investigated.