Ravindra R. Kamble

Bio: Ravindra R. Kamble is an academic researcher from Karnatak University. The author has contributed to research in topics: Sydnone & Chemistry. The author has an hindex of 15, co-authored 97 publications receiving 856 citations. Previous affiliations of Ravindra R. Kamble include University of Mysore.

Polymer Synthesis and Processing

Abstract: Polymer scientists have made an extensive research in the development of biodegradable polymers, which could find enormous applications in the area of medical science. Today, various biopolymers have been prepared and utilized in different biomedical applications. Despite the apparent proliferation of biopolymers in medical science, the science and technology of biopolymers is still in its early stages of development. Tremendous opportunities exist and will continue to exist for the penetration of biopolymers in every facet of medical science through intensive research and development. Therefore, this chapter addresses different polymerization methods and techniques employed for the preparation of biopolymers. The emphasis is on the general properties of biopolymers, synthetic protocols, and their biomedical applications. In order to make the useful biomedical devices from the polymers to meet the demands of medical science, various processing techniques employed for the development of devices have been discussed. Further, perspectives in this field have been highlighted and conclusions arrived at. The relevant literature was collected from different sources, including Google sites, books, and reviews.

A Simple Approach on Synthesis of TiO2 Nanoparticles and its Application in dye Sensitized Solar Cells

Abstract: This paper presents a simple, low cost method of synthesizing TiO2 nanoparticles by sol-gel method, where titanium isopropoxide is used as a starting material. Further, same TiO2 is used to sensitize 2-cyano-3(4-(7-(5-(4(diphenylamino) phenyl)-4octylthiophen-2-yl) benzo[c] [1, 2, 5] thiadiazol-4yl)phenyl) acrylic acid (RK-1 dye) and Di-tetrabutylammonium cis-bis (isothiocyanato) bis (2,2’-bipyridyl4,4’-dicarboxylato) ruthenium(II) (N-719 dye) for light harvesting applications. Anatase structure and average particle size of 7.3 nm were confirmed from XRD pattern. From SEM, it was noticed that particles were of varying size and shape and aggregation with clear porosity. FTIR spectra reveal Ti-O bond corresponding to 483 cm – 1 and from UV-Vis absorption, energy band gap was found to be 3.2 eV. Photocurrent density (J) photovoltage (V) characteristic of DSSC of different thicknesses of TiO2 were obtained, it was observed that optimum solar energy to electricity conversion efficiency () for RK-1 dye and N719 dye 4.08 % and 5.12 % with TiO2 thickness of 5.4 μm and 8.6 μm respectively under AM 1.5 irradiation (1000 W/m2) conditions.

An efficient one-pot cyclization of quinoline thiosemicarbazones to quinolines derivatized with 1,3,4-thiadiazole as anticancer and anti-tubercular agents

Abstract: A series of 6,7,8-substituted thiosemicarbazones (2a–j) of 2-chloro-3-formyl-quinoline derivatives were cyclized to the title compounds (3a–j) using acetic anhydride. The structures of the final compounds (3a–j) were confirmed by elemental and spectral (IR, 1H NMR and MS) analysis. Some of the title compounds have shown promising anticancer and antitubercular activities.

The Principles and Practice of Medicine

Abstract: This work consists of two volumes, and extends over eighteen hundred closely printed pages. In the preface we are informed that the greater part was in manuscript when the pen dropped from the author's hand. The section on Diseases of the Heart was not completed, and that on Diseases of the Skin was not commenced. Dr Wilks has completed the former; while the editor, Dr Pye-Smith, has supplied the latter. The range of the work is the same as that of other treatises on the Principles and Practice of Medicine, while owing to its size greater freedom has necessarily been obtained for a more elaborate treatment of the varied subjects with which such a work deals, than could be possible in one of more restricted dimensions. But this is one of the few large works which one would gladly have had even fuller; its whole contents are of such a quality that curtailment in any section would have been a loss. It is quite impossible in the space at our disposal to critically review the special teaching of the various chapters, and yet without this there is difficulty in conveying anything like an accurate impression of what the book is. Even to class it as the best work

Current Developments of Coumarin Compounds in Medicinal Chemistry

Abstract: Coumarin compounds represent an important type of naturally occurring and synthetic oxygen-containing heterocycles with typical benzopyrone framework. This type of special benzopyrone structure enables its derivatives readily interact with a diversity of enzymes and receptors in organisms through weak bond interactions, thereby exhibit wide potentiality as medicinal drugs. So far, some coumarin-based drugs such as anticoagulant and antineurodegenerative agents have been extensively used in clinic. Coumarin-containing supramolecular medicinal agents as a new increasing expansion of supramolecular chemistry in pharmaceutical science have also been actively investigated in recent years. Coumarin-derived artificial ion receptors, fluorescent probes and biological stains are growing quickly and have a variety of potential applications in monitoring timely enzyme activity, complex biological events as well as accurate pharmacological and pharmacokinetic properties. This review provides a systematic summary and insight of the whole range of medicinal chemistry in the current developments of coumarin compounds as anticoagulant, antineurodegenerative, anticancer, antioxidative, antibacterial, antifungal, antiviral, antiparasitic, antiinflammatory and analgesic, antidiabetic, antidepressive and other bioactive agents as well as supramolecular medicinal drugs, diagnostic agents and pathologic probes, and biological stains. Some rational design strategies, structure-activity relationships and action mechanisms are discussed. The perspectives of the future development of coumarinbased medicinal chemistry are also presented.