Author
Raymond J. Giguere
Bio: Raymond J. Giguere is an academic researcher from Mercer University. The author has contributed to research in topics: Intramolecular force & Ene reaction. The author has an hindex of 3, co-authored 6 publications receiving 1089 citations.
Papers
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TL;DR: In this article, commercial microwave ovens have been safely used to dramatically reduce the reaction times (at comparable yield) of Diels-Alder, Claisen, and ene reactions.
1,028 citations
TL;DR: Tandem ene/intramolecular Diels-Alder reactions of 1,4-cyclohexadiene and mono-activated acetylenes are optimized in this paper.
75 citations
TL;DR: In this paper, the Hoffmann-Noyori reaction of acyclic trienol 6 permits direct entry to hydoazulenes 7a, b with modest diastereoselectivity.
31 citations
TL;DR: In this paper, commercial microwave ovens have been safely used to dramatically reduce the reaction times (at comparable yield) of Diels-Alder, Claisen, and ene reactions.
Abstract: Commercial microwave ovens have been safely used to dramatically reduce the reaction times (at comparable yield) of Diels-Alder, Claisen, and ene reactions. Significant solvent effects were also observed.
17 citations
TL;DR: Tandem ene/intramolecular Diels-Alder reactions of 1,4-cyclohexadiene and mono-activated acetylenes are optimized in this paper.
Abstract: Tandem ene/intramolecular Diels-Alder reactions of 1,4-cyclohexadiene and mono - or di -activated acetylenes are optimized. Analogous reactions with disubstituted bicyclohexa-1,4-dienes regioselectively produce highly functionalized tetracyclic adducts.
Cited by
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TL;DR: This Review highlights recent applications of controlled microwave heating in modern organic synthesis, and discusses some of the underlying phenomena and issues involved.
Abstract: Although fire is now rarely used in synthetic chemistry, it was not until Robert Bunsen invented the burner in 1855 that the energy from this heat source could be applied to a reaction vessel in a focused manner. The Bunsen burner was later superseded by the isomantle, oil bath, or hot plate as a source for applying heat to a chemical reaction. In the past few years, heating and driving chemical reactions by microwave energy has been an increasingly popular theme in the scientific community. This nonclassical heating technique is slowly moving from a laboratory curiosity to an established technique that is heavily used in both academia and industry. The efficiency of "microwave flash heating" in dramatically reducing reaction times (from days and hours to minutes and seconds) is just one of the many advantages. This Review highlights recent applications of controlled microwave heating in modern organic synthesis, and discusses some of the underlying phenomena and issues involved.
3,044 citations
1,321 citations
TL;DR: An overview of the mechanism of this remarkable reaction is presented as a means to explain the myriad of experimental results, particularly the various methods of catalyst generation, solvent and substrate effects, and choice of base or ligand as discussed by the authors.
1,319 citations
TL;DR: In this paper, microwave-accelerated solventless organic syntheses are summarised and the salient features of these high yield protocols are the enhanced reaction rates, greater selectivity and the experimental ease of manipulation.
1,190 citations
TL;DR: In this paper, the principles underlying the dielectric heating effects observed for chemical compounds in solution and in the solid state are presented, and applications of the technique to a wide range of chemical syntheses have also been indicated.
Abstract: This review has presented the principles underlying the dielectric heating effects observed for chemical compounds in solution and in the solid state. The applications of the technique to a wide range of chemical syntheses have also been indicated. The field is in its infancy and therefore much of the effort to date has been directed towards understanding the rate enhancements of known reactions. The next few years should see the isolation of new compounds using microwave heating techniques
1,067 citations