R
Raymond R. Tice
Researcher at Research Triangle Park
Publications - 39
Citations - 7302
Raymond R. Tice is an academic researcher from Research Triangle Park. The author has contributed to research in topics: DNA damage & Micronucleus test. The author has an hindex of 23, co-authored 39 publications receiving 6987 citations. Previous affiliations of Raymond R. Tice include National Institutes of Health.
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Journal ArticleDOI
Single cell gel/comet assay: guidelines for in vitro and in vivo genetic toxicology testing.
Raymond R. Tice,E. Agurell,Diana Anderson,B. Burlinson,Andreas Hartmann,H. Kobayashi,Y. Miyamae,Emilio Rojas,J.-C. Ryu,Y. F. Sasaki +9 more
TL;DR: The expert panel reached a consensus that the optimal version of the Comet assay for identifying agents with genotoxic activity was the alkaline (pH > 13) versions of the assay developed by Singh et al.
Journal ArticleDOI
In vivo rodent erythrocyte micronucleus assay.
M. Hayashi,Raymond R. Tice,James T. MacGregor,Diana Anderson,David H. Blakey,M. Kirsh-Volders,Frederick F.B. Oleson,Francesca Pacchierotti,Felix F. Romagna,Hiroyasu Shimada,Sizuyo Sutou,B. Vannier +11 more
TL;DR: Although a consensus was not achieved, operationally it was agreed that 2000 cells per animal and four animals per group was a minimum requirement, in general, the available database suggests that the use of one gender is adequate for screening.
Journal ArticleDOI
A microgel electrophoresis technique for the direct quantitation of DNA damage and repair in individual fibroblasts cultured on microscope slides
TL;DR: The single-cell gel electrophoretic (SCG) technique for the in situ quantitation of DNA single-strand breaks and alkali-labile sites in cultured human-fibroblasts is standardized and applications for in vitro toxicology are discussed.
Journal ArticleDOI
DNA damage and rpair with age in individual human lymphocytes
TL;DR: Data indicate an age-related decline in DNA repair competence among a small subpopulation of lymphocytes in lymphocytes exposed in vitro to 200 rads of X-irradiation.
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Genotoxicity of radiofrequency signals. I. Investigation of DNA damage and micronuclei induction in cultured human blood cells.
TL;DR: It is demonstrated that, under extended exposure conditions, RF signals at an average SAR of at least 5.0 W/kg are capable of inducing chromosomal damage in human lymphocytes, and independent of the technology, the presence or absence of voice modulation, and the frequency.