R
Rebecca A. Muhle
Researcher at Albert Einstein College of Medicine
Publications - 14
Citations - 1912
Rebecca A. Muhle is an academic researcher from Albert Einstein College of Medicine. The author has contributed to research in topics: Medicine & Internal medicine. The author has an hindex of 7, co-authored 8 publications receiving 1695 citations. Previous affiliations of Rebecca A. Muhle include Columbia University Medical Center.
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Journal ArticleDOI
The Genetics of Autism
TL;DR: Significant evidence is found for multiple interacting genetic factors as the main causative determinants of autism and for interactions between multiple genes cause "idiopathic" autism but that epigenetic factors and exposure to environmental modifiers may contribute to variable expression of autism-related traits.
Journal ArticleDOI
Efficient site-specific integration in Plasmodium falciparum chromosomes mediated by mycobacteriophage Bxb1 integrase
Louis J. Nkrumah,Rebecca A. Muhle,Pedro A. Moura,Pallavi Ghosh,Graham F. Hatfull,Graham F. Hatfull,William R. Jacobs,David A. Fidock +7 more
TL;DR: An efficient, site-specific system of genetic integration into Plasmodium falciparum malaria parasite chromosomes mediated by mycobacteriophage Bxb1 integrase is reported, which illustrates the utility of Bxa1-based integrative recombination for genetic studies of intracellular eukaryotic organisms.
Journal ArticleDOI
A critical role for PfCRT K76T in Plasmodium falciparum verapamil-reversible chloroquine resistance
Viswanathan Lakshmanan,Patrick G. Bray,Dominik Verdier-Pinard,David J. Johnson,Paul Horrocks,Rebecca A. Muhle,George E Alakpa,Ruth H Hughes,Steve A. Ward,Donald J. Krogstad,Amar Bir Singh Sidhu,David A. Fidock +11 more
TL;DR: Findings establish PfCRT K76T as a critical component of CQR and suggest that CQ access to ferriprotoporphyrin IX is determined by drug–protein interactions involving this mutant residue.
Journal ArticleDOI
Chloroquine resistance modulated in vitro by expression levels of the Plasmodium falciparum chloroquine resistance transporter.
Karena L. Waller,Rebecca A. Muhle,Lyann M. B. Ursos,Paul Horrocks,Dominik Verdier-Pinard,Amar Bir Singh Sidhu,Hisashi Fujioka,Paul D. Roepe,David A. Fidock +8 more
TL;DR: Genetic truncation of 3′-untranslated regions provides a useful approach for assessing the impact of candidate genes on drug resistance or other quantifiable phenotypes in P. falciparum.
Journal ArticleDOI
Association of Birth During the COVID-19 Pandemic With Neurodevelopmental Status at 6 Months in Infants With and Without In Utero Exposure to Maternal SARS-CoV-2 Infection.
Lauren C. Shuffrey,Morgan R. Firestein,Margaret H. Kyle,Andrea Cora Fields,Carmela Alcántara,Dima Amso,Judy Austin,Jennifer M. Bain,Jennifer R. Barbosa,Mary L. Bence,Catherine Bianco,Cristina R. Fernández,Sylvie Goldman,Cynthia Gyamfi-Bannerman,Violet Hott,Yunzhe Hu,Maha Hussain,Pam Factor-Litvak,Maristella Lucchini,Arthur M. Mandel,Rachel Marsh,Danielle McBrian,Mirella Mourad,Rebecca A. Muhle,Kimberly G. Noble,Anna A. Penn,Cynthia Rodriguez,Ayesha Sania,Wendy Silver,Kally C. O'Reilly,Melissa S. Stockwell,Nim Tottenham,Martha G. Welch,Noelia Zork,William P. Fifer,Catherine Monk,Dani Dumitriu +36 more
TL;DR: Birth during the pandemic, but not in utero exposure to maternal SARS-CoV-2 infection, was associated with differences in neurodevelopment at age 6 months, and these early findings support the need for long-term monitoring of children born during the COVID-19 pandemic.