Rebecca M Haley

TL;DR: Advances in nanoparticle design that overcome heterogeneous barriers to delivery are discussed, arguing that intelligent nanoparticles design can improve efficacy in general delivery applications while enabling tailored designs for precision applications, thereby ultimately improving patient outcome overall.

TL;DR: This review comments on a sampling of existing methods for localized or targeted delivery of non-steroidal anti-inflammatory drugs, with the goal of helping future research groups to focus on bettering methods shown to be effective and filling the gaps of knowledge in this field.

TL;DR: Current work in gene therapy which utilizes the cyclic oligosaccharide molecule cyclodextrin (CD) is highlighted, showing great promise in combination therapies, and the use of combination and personalized therapies, such as those which incorporate CD.

TL;DR: In vivo results indicated that the pCD delivery system successfully delivered resveratrol to the brain with a sustained release for the entire short-duration study (up to 7 days) and in vivo results provided support for the possibility of improving the delivery of resver atrol in an attempt to stabilize long-term neural interfacing applications.

TL;DR: Through testing, it has been shown that the fabrication of the pCD coating minimally affects the suture's mechanical properties, and the therapeutic level of this delivery is sufficient to show inhibition of bacterial growth for 4 weeks, and free-radical scavenging for 2”weeks.