R
Reda Karaliuskas
Researcher at University of Chicago
Publications - 2
Citations - 4838
Reda Karaliuskas is an academic researcher from University of Chicago. The author has contributed to research in topics: Interleukin-23 receptor & Mutant. The author has an hindex of 1, co-authored 2 publications receiving 4679 citations.
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A frameshift mutation in NOD2 associated with susceptibility to Crohn's disease
Yasunori Ogura,Denise K. Bonen,Naohiro Inohara,Dan L. Nicolae,Felicia F. Chen,Richard Ramos,Heidi M. Britton,Thomas M. Moran,Reda Karaliuskas,Richard H. Duerr,Jean-Paul Achkar,Steven R. Brant,Theodore M. Bayless,Barbara S. Kirschner,Stephen B. Hanauer,Gabriel Núñez,Judy H. Cho +16 more
TL;DR: It is shown that a frameshift mutation caused by a cytosine insertion, 3020insC, which is expected to encode a truncated NOD2 protein, is associated with Crohn's disease, and a link between an innate immune response to bacterial components and development of disease is suggested.
We acknowledge patients and their families, and thank family recruitment doctors:
J. Balanzo,Bruno Bonaz,Yoram Bouhnik,G. Cadiot,Salvatore Cucchiara,B. Crusius,J. J. Delchier,B. Duclos,J.L. Dupas,J. P. Galmiche,Jean-Pierre Gendre,D. Golfain,D. Heresbach,A. Lachaux,H. Lautraite,C. Lenaerts,Eric Lerebours,V. Levy,H Malchow,P. Marteau,A. Morali,Francesco Pallone,S. A. Peña,A. Rotenberg,I. Rousseau,J. Schmitz,Fergus Shanahan,Iradj Sobhani,H. Svensson,A. Van Gossum,M. Van Winckel,Michel Veyrac,Yasunori Ogura,Denise K. Bonen,Naohiro Inohara,Dan L. Nicolae,Felicia F. Chen,Richard Ramos,Heidi M. Britton,Thomas M. Moran,Reda Karaliuskas,Richard H. Duerrk,Steven R. Brant,Theodore M. Bayless,Barbara S. Kirschner,Stephen B. Hanauer,Judy H. Cho +46 more