Author
Reesa Mercado
Bio: Reesa Mercado is an academic researcher. The author has contributed to research in topics: Antimicrobial. The author has an hindex of 1, co-authored 1 publications receiving 7 citations.
Topics: Antimicrobial
Papers
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7 citations
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TL;DR: A novel series of N-benzenesulfonyl-1,2,3,4-tetrahydroisoquinoline-triazoles containing triazole moiety were designed and synthesized through rational cycloadditions using the modified Pictet-Spengler reaction and the Click chemistry and showed stronger anticancer activity against HepG2 cells than that of the etoposide.
46 citations
TL;DR: The presence of a benzenesulfonyl moiety improves the antiparasitic activity of the heterocycles included in this study (with the exception of Trypanosoma brucei rhodesiense), validating the criteria used in the selection of the privileged structures and diversification used to generate this library.
14 citations
TL;DR: To investigate potential antimicrobial activities of Verbesina negrensis, crude extracts from plant aerial structures were evaluated and the active compound was characterized as 6β-cinnamoyloxy-1β-hydroxy-10α-metoxy-3-oxo-germacra-4,5Z-ene, which inhibited both E. faecalis and S. aureus.
Abstract: Several health benefits have been attributed to members of the
Verbesina genus, including promotion of urinary and
gastrointestinal health. Verbesina species are also reported to
exhibit antibacterial, antiparasitic, and antioxidant activities. Although
members of the Verbesina genus produce various pharmacologically
relevant chemicals as secondary metabolites, including eudesmanes,
flavonoids, guanidine alkaloids, acetylenic compounds, and germacrenes, the
active compounds required for these benefits remain unknown. To investigate
potential antimicrobial activities of Verbesina negrensis, crude
extracts from plant aerial structures were evaluated. Following chemical
fractionation, the chloroformic extract from Verbesina negrensis was
subjected to bioassay-guided isolation using disk diffusion assays to
determine antimicrobial activity. The active compound was characterized as
6β-cinnamoyloxy-1β-hydroxy-10α-metoxy-3-oxo-germacra-4,5Z-ene
(1). Fractions containing 1 inhibited both Enterococcus
faecalis (ATCC 29 212) and Staphylococcus aureus (ATCC
29213). The MIC for 1 was determined by microbroth dilution assay to
be 64 µg/mL for both E. faecalis and S. aureus.
9 citations
TL;DR: Overall, the results demonstrated that the studied BSTHQ derivatives elicit their antibacterial activity by interacting with a specific molecular target, GlmU being the highly feasible one.
Abstract: The development of new antibiotics with activity towards a broad spectrum of bacteria, including multiresistant strains, is a very important topic for global public health. As part of previous work...
6 citations
TL;DR: In this article, a combined experimental and theoretical study of N-benzenesulfonyl-1H-1,2,3-benzotriazole (NBSBZT) is communicated.
3 citations