R
Regina Z. Cer
Researcher at Naval Medical Research Center
Publications - 44
Citations - 2078
Regina Z. Cer is an academic researcher from Naval Medical Research Center. The author has contributed to research in topics: Medicine & Genome. The author has an hindex of 16, co-authored 35 publications receiving 1790 citations. Previous affiliations of Regina Z. Cer include Henry M. Jackson Foundation for the Advancement of Military Medicine & Science Applications International Corporation.
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Journal ArticleDOI
Identification of anthrax toxin genes in a Bacillus cereus associated with an illness resembling inhalation anthrax
Alex R. Hoffmaster,Jacques Ravel,David A. Rasko,Gail D. Chapman,Michael D. Chute,Chung K. Marston,Barun K. De,Claudio Tavares Sacchi,Collette Fitzgerald,Leonard W. Mayer,Martin C. J. Maiden,Fergus G. Priest,Margaret Barker,Lingxia Jiang,Regina Z. Cer,Jennifer Rilstone,Scott N. Peterson,Robbin S. Weyant,Darrell R. Galloway,Timothy D. Read,Tanja Popovic,Claire M. Fraser +21 more
TL;DR: A public health approach with genome analysis is combined to provide insight into the correlation of phenotypic characteristics and their genetic basis and represents an example of how genomics could rapidly assist public health experts responding not only to clearly identified select agents but also to novel agents with similar pathogenic potentials.
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IC50-to-Ki: a web-based tool for converting IC50 to Ki values for inhibitors of enzyme activity and ligand binding
TL;DR: A new web-server tool estimates Ki values from experimentally determined IC50 values for inhibitors of enzymes and of binding reactions between macromolecules and ligands to enable end users to help gauge the quality of the underlying assumptions used in these calculations.
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The genome sequence of Bacillus cereus ATCC 10987 reveals metabolic adaptations and a large plasmid related to Bacillus anthracis pXO1
David A. Rasko,Jacques Ravel,Ole Andreas Økstad,Erlendur Helgason,Regina Z. Cer,Lingxia Jiang,Kelly A. Shores,Derrick E. Fouts,Nicolas J. Tourasse,Samuel V. Angiuoli,James F. Kolonay,William C. Nelson,Anne-Brit Kolstø,Claire M. Fraser,Timothy D. Read +14 more
TL;DR: The complete genome of Bacillus cereus ATCC 10987, a non-lethal dairy isolate in the same genetic subgroup as Bacillus anthracis, is sequenced and shows chromosomal similarity to B.anthracis pXO1 but is lacking the pathogenicity-associated island containing the anthrax lethal and edema toxin complex genes.
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Complete Sequence Analysis of Novel Plasmids from Emetic and Periodontal Bacillus cereus Isolates Reveals a Common Evolutionary History among the B. cereus-Group Plasmids, Including Bacillus anthracis pXO1
David A. Rasko,M. J. Rosovitz,Ole Andreas Økstad,Derrick E. Fouts,Lingxia Jiang,Regina Z. Cer,Anne-Brit Kolstø,Steven R. Gill,Jacques Ravel +8 more
TL;DR: It is demonstrated that the pXO1-like plasmids may define pathogenic B. cereus isolates in the same way that p XO1 and pXo2 define the B. anthracis species.
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Non-B DB v2.0: a database of predicted non-B DNA-forming motifs and its associated tools
Regina Z. Cer,Regina Z. Cer,Duncan E. Donohue,Uma Mudunuri,Nuri A. Temiz,Michael A. Loss,Nathan J. Starner,Goran N. Halusa,Natalia Volfovsky,Ming Yi,Brian T. Luke,Albino Bacolla,Jack R. Collins,Robert M. Stephens +13 more
TL;DR: The non-B DNA-forming sequence motif database (nonb.abcc.ncifcrf.gov) as mentioned in this paper catalogs predicted sequence motifs, including Z-DNA, G-quadruplex, A-phased repeats, inverted repeats, mirror repeats, direct repeats and their corresponding subsets: cruciforms, triplexes and slipped structures, in several genomes.