R
Rei Otsu
Researcher at Osaka University
Publications - 15
Citations - 557
Rei Otsu is an academic researcher from Osaka University. The author has contributed to research in topics: Inflammation & Angiogenesis. The author has an hindex of 11, co-authored 15 publications receiving 406 citations.
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Journal ArticleDOI
Source of Chronic Inflammation in Aging.
Fumihiro Sanada,Yoshiaki Taniyama,Jun Muratsu,Rei Otsu,Hideo Shimizu,Hiromi Rakugi,Ryuichi Morishita +6 more
TL;DR: The factors and cellular pathways/processes that are known to regulate low-grade persistent inflammation in aging and age-related disease are summarized.
Journal ArticleDOI
Selective Blockade of Periostin Exon 17 Preserves Cardiac Performance in Acute Myocardial Infarction.
Yoshiaki Taniyama,Naruto Katsuragi,Fumihiro Sanada,Junya Azuma,Kazuma Iekushi,Nobutaka Koibuchi,Keita Okayama,Yuka Ikeda-Iwabu,Jun Muratsu,Rei Otsu,Hiromi Rakugi,Ryuichi Morishita +11 more
TL;DR: Results indicate that therapeutics that specifically inhibit Pn exon-17, via a neutralizing antibody or drug, without suppressing other perisotin variants might offer a new class of medication for the treatment of acute myocardial infarction patients.
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Telmisartan Exerts Renoprotective Actions via Peroxisome Proliferator-Activated Receptor-γ/Hepatocyte Growth Factor Pathway Independent of Angiotensin II Type 1 Receptor Blockade
Hiroshi Kusunoki,Yoshiaki Taniyama,Junya Azuma,Kazuma Iekushi,Fumihiro Sanada,Rei Otsu,Masaaki Iwabayashi,Keita Okayama,Hiromi Rakugi,Ryuichi Morishita +9 more
TL;DR: Evidence is provided of organ protective actions of telmisartan through the PPAR&ggr;/HGF pathway, independent of Ang II type 1 receptor blockade, which might provide new beneficial drugs to treat renal and cardiovascular diseases.
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Local Production of Activated Factor X in Atherosclerotic Plaque Induced Vascular Smooth Muscle Cell Senescence
Fumihiro Sanada,Jun Muratsu,Rei Otsu,Hideo Shimizu,Nobutaka Koibuchi,Kazutaka Uchida,Yoshiaki Taniyama,Shinichi Yoshimura,Hiromi Rakugi,Ryuichi Morishita +9 more
TL;DR: In this paper, the effects of coagulation factor Xa (FXa) on the growth of vascular smooth muscle cells (VSMC), inflammatory cells, and endothelial cells were examined.
Journal ArticleDOI
IGF Binding Protein-5 Induces Cell Senescence.
Fumihiro Sanada,Yoshiaki Taniyama,Jun Muratsu,Rei Otsu,Hideo Shimizu,Hiromi Rakugi,Ryuichi Morishita +6 more
TL;DR: The accumulating evidence for the role of IGFBP-5 seems to play decisive roles in controlling cell senescence and cell inflammation is described, including a new finding.