R
Reiner U. Jänicke
Researcher at National University of Singapore
Publications - 19
Citations - 7485
Reiner U. Jänicke is an academic researcher from National University of Singapore. The author has contributed to research in topics: Apoptosis & Programmed cell death. The author has an hindex of 16, co-authored 19 publications receiving 6949 citations.
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Journal ArticleDOI
Emerging roles of caspase-3 in apoptosis
Alan G. Porter,Reiner U. Jänicke +1 more
TL;DR: Caspase-3 is essential for certain processes associated with the dismantling of the cell and the formation of apoptotic bodies, but it may also function before or at the stage when commitment to loss of cell viability is made.
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Caspase-3 Is Required for DNA Fragmentation and Morphological Changes Associated with Apoptosis
TL;DR: Results indicate that although caspase-3 is not essential for TNF- or staurosporine-induced apoptosis, it is required for DNA fragmentation and some of the typical morphological changes of cells undergoing apoptosis.
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Caspase-3 Is Required for α-Fodrin Cleavage but Dispensable for Cleavage of Other Death Substrates in Apoptosis
TL;DR: It is suggested that caspase-3 is essential for cleavage of α-fodrin, but dispensable for the cleaved of PARP, Rb, PAK2, DNA-PKcs, gelsolin, and DFF-45 and imply that one or more caspases other than caspasing 2, 3, and 7 is activated and plays a crucial role in the cleaving of these substrates in MCF-7 cells.
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Single-cell fluorescence resonance energy transfer analysis demonstrates that caspase activation during apoptosis is a rapid process. Role of caspase-3.
Markus Rehm,Heiko Düssmann,Reiner U. Jänicke,Jeremy M. Tavaré,Donat Kögel,Jochen H. M. Prehn +5 more
TL;DR: In this article, the authors examined the cleavage kinetics at the single-cell level by fluorescence resonance energy transfer (FRET) analysis and found that caspase activation during apoptosis occurs in an "all or nothing" fashion.
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Specific cleavage of the retinoblastoma protein by an ICE-like protease in apoptosis.
TL;DR: The results suggest that Rb cleavage is an important event in apoptosis, as Rb suppresses cell death and its C‐terminus has important regulatory functions.