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Reinhard Engels
Researcher at Broad Institute
Publications - 13
Citations - 4307
Reinhard Engels is an academic researcher from Broad Institute. The author has contributed to research in topics: Genome & Gene. The author has an hindex of 11, co-authored 13 publications receiving 4037 citations. Previous affiliations of Reinhard Engels include Massachusetts Institute of Technology & Stanford University.
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Journal ArticleDOI
The genome sequence of the filamentous fungus Neurospora crassa
James E. Galagan,Sarah E. Calvo,Katherine A. Borkovich,Eric U. Selker,Nick O. Read,David B. Jaffe,William Fitzhugh,Li-Jun Ma,Serge Smirnov,Seth Purcell,Bushra Rehman,Timothy Elkins,Reinhard Engels,Shunguang Wang,Cydney B. Nielsen,Jonathan Butler,Matthew G. Endrizzi,Dayong Qui,Peter Ianakiev,Deborah Bell-Pedersen,Mary Anne Nelson,Margaret Werner-Washburne,Claude P. Selitrennikoff,John A. Kinsey,Edward L. Braun,Alex Zelter,Alex Zelter,Ulrich Schulte,Gregory O. Kothe,Gregory Jedd,Werner Mewes,Chuck Staben,Edward M. Marcotte,David Greenberg,Alice Roy,Karen Foley,Jerome Naylor,Nicole Stange-Thomann,Robert Barrett,Sante Gnerre,Michael Kamal,Manolis Kamvysselis,Evan Mauceli,Cord Bielke,Stephen Rudd,Dmitrij Frishman,Svetlana Krystofova,Carolyn G. Rasmussen,Robert L. Metzenberg,David D. Perkins,Scott Kroken,Carlo Cogoni,Giuseppe Macino,David E. A. Catcheside,Weixi Li,Robert J. Pratt,Stephen A. Osmani,Colin P.C. DeSouza,Louise Glass,Marc J. Orbach,J. Andrew Berglund,Rodger B. Voelker,Oded Yarden,Michael Plamann,Stephan Seiler,Jay C. Dunlap,Alan Radford,Rodolfo Aramayo,Donald O. Natvig,Lisa A. Alex,Gertrud Mannhaupt,Daniel J. Ebbole,Michael Freitag,Ian T. Paulsen,Matthew S. Sachs,Eric S. Lander,Chad Nusbaum,Bruce W. Birren +77 more
TL;DR: A high-quality draft sequence of the N. crassa genome is reported, suggesting that RIP has had a profound impact on genome evolution, greatly slowing the creation of new genes through genomic duplication and resulting in a genome with an unusually low proportion of closely related genes.
Journal ArticleDOI
The Genome of M. Acetivorans Reveals Extensive Metabolic and Physiological Diversity
James E. Galagan,Chad Nusbaum,Alice Roy,Matthew G. Endrizzi,Matthew G. Endrizzi,Matthew G. Endrizzi,Pendexter Macdonald,Pendexter Macdonald,Pendexter Macdonald,William Fitzhugh,Sarah E. Calvo,Reinhard Engels,Serge Smirnov,Deven Atnoor,Adam Brown,Nicole R. Allen,Nicole R. Allen,Nicole R. Allen,Jerome Naylor,Nicole Stange-Thomann,Kurt DeArellano,Robin Johnson,Lauren Linton,Paul A. McEwan,Kevin McKernan,Jessica A. Talamas,Andrea Tirrell,Andrea Tirrell,Wenjuan Ye,Wenjuan Ye,Andrew Zimmer,Robert D. Barber,Isaac K. O. Cann,David E. Graham,David A. Grahame,Adam M. Guss,Reiner Hedderich,Cheryl Ingram-Smith,Cheryl Ingram-Smith,Cheryl Ingram-Smith,H. Craig Kuettner,Joseph A. Krzycki,Joseph A. Krzycki,John A. Leigh,Weixi Li,Jinfeng Liu,Biswarup Mukhopadhyay,John N. Reeve,Kerry S. Smith,Timothy A. Springer,Timothy A. Springer,Timothy A. Springer,Lowell Umayam,Owen White,Robert H. White,Everly Conway de Macario,Everly Conway de Macario,James G. Ferry,Ken F. Jarrell,Ken F. Jarrell,Hua Jing,Hua Jing,Hua Jing,Alberto J.L. Macario,Ian T. Paulsen,Ian T. Paulsen,Ian T. Paulsen,Matthew A. Pritchett,Kevin R. Sowers,Ronald V. Swanson,Steven H. Zinder,Steven H. Zinder,Eric S. Lander,Eric S. Lander,Eric S. Lander,William W. Metcalf,Bruce W. Birren +76 more
TL;DR: The complete genome sequence of an acetate-utilizing methanogen, Methanosarcina acetivorans C2A, is reported, which indicates the likelihood of undiscovered natural energy sources for methanogenesis, whereas the presence of single-subunit carbon monoxide dehydrogenases raises the possibility of nonmethanogenic growth.
Journal ArticleDOI
Dynamics of Pseudomonas aeruginosa genome evolution.
Kalai Mathee,Giri Narasimhan,Camilo Valdes,Xiaoyun Qiu,Jody M. Matewish,Michael Koehrsen,Antonis Rokas,Chandri N. Yandava,Reinhard Engels,Erliang Zeng,Raquel Olavarietta,Melissa Doud,Roger S. Smith,Philip Montgomery,Jared White,Paul A. Godfrey,Chinnappa D. Kodira,Bruce W. Birren,James E. Galagan,Stephen Lory +19 more
TL;DR: The complete sequence and comparative analysis of the genomes of two representative P. aeruginosa strains isolated from cystic fibrosis patients whose genetic disorder predisposes them to infections by this pathogen suggest that niche adaptation is a major evolutionary force influencing the composition of bacterial genomes.
Journal ArticleDOI
Comparative Genomics Yields Insights into Niche Adaptation of Plant Vascular Wilt Pathogens
Steven J. Klosterman,Krishna V. Subbarao,Seogchan Kang,Paola Veronese,Scott E. Gold,Bart P. H. J. Thomma,Zehua Chen,Bernard Henrissat,Yong-Hwan Lee,Jongsun Park,María D. García-Pedrajas,Dez J. Barbara,Amy Anchieta,Ronnie de Jonge,Parthasarathy Santhanam,Karunakaran Maruthachalam,Zahi K. Atallah,Stefan G. Amyotte,Zahi Paz,Patrik Inderbitzin,Ryan J. Hayes,David I. Heiman,Sarah Young,Qiandong Zeng,Reinhard Engels,James E. Galagan,Christina A. Cuomo,Katherine F. Dobinson,Katherine F. Dobinson,Li-Jun Ma,Li-Jun Ma +30 more
TL;DR: Insight is revealed into the genetic mechanisms of niche adaptation of fungal wilt pathogens, advances the understanding of the evolution and development of their pathogenesis, and sheds light on potential avenues for the development of novel disease management strategies to combat destructive wilt diseases.
Journal ArticleDOI
Genomic Analysis of the Basal Lineage Fungus Rhizopus oryzae Reveals a Whole-Genome Duplication
Li-Jun Ma,Ashraf S. Ibrahim,Christopher D. Skory,Manfred Grabherr,Gertraud Burger,Margi I. Butler,Marek Eliáš,Alexander Idnurm,B. Franz Lang,Teruo Sone,Ayumi Abe,Sarah E. Calvo,Luis M. Corrochano,Reinhard Engels,Jianmin Fu,Wilhelm Hansberg,Jung Mi Kim,Chinnappa D. Kodira,Michael Koehrsen,Bo Liu,Diego Miranda-Saavedra,Sinéad B. O'Leary,Lucila Ortiz-Castellanos,Russell T. M. Poulter,Julio Rodríguez-Romero,José Ruiz-Herrera,Yao Qing Shen,Qiandong Zeng,James E. Galagan,Bruce W. Birren,Christina A. Cuomo,Brian L. Wickes +31 more
TL;DR: The order and genomic arrangement of the duplicated gene pairs and their common phylogenetic origin provide evidence for an ancestral whole-genome duplication (WGD) event that resulted in the expansion of multiple gene families related to cell growth and signal transduction, as well as secreted aspartic protease and subtilase protein families, which are known fungal virulence factors.