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Reinhard Gabathuler

Bio: Reinhard Gabathuler is an academic researcher. The author has contributed to research in topics: Drug delivery to the brain & Transcytosis. The author has an hindex of 1, co-authored 1 publications receiving 654 citations.

Papers
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TL;DR: The low density lipoprotein receptor related protein (LRP) is the most adapted for such use with the engineered peptide compound (EPiC) platform incorporating the Angiopep peptide in new therapeutics the most advanced with promising data in the clinic.

735 citations


Cited by
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TL;DR: Two important aspects of nanomedicine, drug delivery and tissue engineering are discussed, highlighting the advances the authors have recently experienced, the challenges they are currently facing, and what they are likely to witness in the near future.
Abstract: The application of nanotechnology in medicine, referred to as nanomedicine, is offering numerous exciting possibilities in healthcare. Herein, we discuss two important aspects of nanomedicine, drug delivery and tissue engineering, highlighting the advances we have recently experienced, the challenges we are currently facing, and what we are likely to witness in the near future.

1,377 citations

Journal ArticleDOI
TL;DR: This review will discuss the barrier issue from a biological and pathological perspective to provide a better insight to the challenges and opportunities associated with the BBB.

772 citations

Journal ArticleDOI
TL;DR: The key issues in translating BDNF biology into synaptic repair therapies are reviewed, which pave the way for a 'synaptic repair' therapy for neurodegenerative diseases that targets pathophysiology rather than pathogenesis.
Abstract: Synaptic dysfunction is a key pathophysiological hallmark in several neurodegenerative disorders. In this Review, Lu and colleagues consider a 'synaptic repair'-based therapy for neurodegenerative diseases that targets pathophysiology rather than pathogenesis and discuss BDNF as a potential synaptic repair molecule.

589 citations

Journal ArticleDOI
TL;DR: Recent evidence supporting important roles for astrocytes in neuropathological conditions such as neuroinflammation, amyotrophic lateral sclerosis and Alzheimer's disease is discussed and the potential for neuroprotective therapeutics based on the modulation of astroCytic functions is explored.

575 citations

Journal ArticleDOI
TL;DR: The delivery of drugs, which usually are not able to cross the BBB, into the brain was confirmed by the biodistribution studies and pharmacological assays in rodents, and the presence of nanoparticles in the brain parenchyma was visualized by electron microscopy, suggesting that this technology holds great promise for non-invasive therapy of the CNS diseases.

558 citations