Reinhard Krepler

TL;DR: During cell transformation and tumor devel- opment this cell type specificity of intermediate filaments is largely conserved’ and classification of tumors by their specific type of intermediate Filaments has re- cently become very valuable in clinical histodiagnosis.

TL;DR: Individual cytokeratins provide tissue- or cell type-specific markers that are useful in the definition and identification of the relatedness or the origin of epithelial and carcinoma cells.

TL;DR: Using cytoskeletal proteins from human biopsies and autopsies, the cytokeratin polypeptide patterns of diverse primary and metastatic carcinomas are examined and compared with those of corresponding normal epithelial tissues and cultured cells and the possibility of cell type heterogeneity within a given tumor is discussed.

TL;DR: The results show that the various epithelia present in skin, albeit in physical and ontogenic continuity, can be distinguished by their specific cytokeratin- polypeptide patterns and that the cytoskeleton of basal-cell epitheliomas is related to that of cells of the pilosebaceous tract.

TL;DR: The results show that immunologic and biochemical analysis of proteins associated with the intermediate filament cytoskeleton is a useful adjunct in the diagnosis of diverse neoplasms, particularly those with equivocal histologic features, and thus aids in the histogenetic classification of soft tissue tumors.