R
Reinhard Lührmann
Researcher at Max Planck Society
Publications - 359
Citations - 38536
Reinhard Lührmann is an academic researcher from Max Planck Society. The author has contributed to research in topics: snRNP & Spliceosome. The author has an hindex of 104, co-authored 357 publications receiving 36117 citations. Previous affiliations of Reinhard Lührmann include University of Marburg.
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Journal ArticleDOI
The Spliceosome: Design Principles of a Dynamic RNP Machine
TL;DR: The spliceosome exhibits exceptional compositional and structural dynamics that are exploited during substrate-dependent complex assembly, catalytic activation, and active site remodeling in the pre-mRNAs.
Journal ArticleDOI
Single-stranded antisense siRNAs guide target RNA cleavage in RNAi
TL;DR: A human biochemical system that recapitulates siRNA-mediated target RNA degradation by using affinity-tagged siRNAs is described and it is demonstrated that a single-stranded siRNA resides in the RNA-induced silencing complex (RISC) together with eif2C1 and/or eIF2C2 (human GERp95) Argonaute proteins.
Journal ArticleDOI
Spliceosome structure and function.
Cindy L. Will,Reinhard Lührmann +1 more
TL;DR: The extensive interplay of RNA and proteins in aligning the pre-mRNA's reactive groups, and the presence of both RNA and protein at the core of the splicing machinery, suggest that the spliceosome is an RNP enzyme, but elucidation of the precise nature of its active site awaits the generation of a high-resolution structure of its RNP core.
Journal ArticleDOI
The HIV-1 Rev activation domain is a nuclear export signal that accesses an export pathway used by specific cellular RNAs.
TL;DR: The Rev activation domain constitutes a nuclear export signal that redirects RRE-containing viral RNAs to a non-mRNA export pathway.
Journal ArticleDOI
Spliceosomal UsnRNP biogenesis, structure and function.
Cindy L. Will,Reinhard Lührmann +1 more
TL;DR: U2 and U4/U6*U5 tri-snRNPs functionally associate with the pre-mRNA at an earlier stage of spliceosome assembly than previously thought, and additional evidence supporting UsnRNA-mediated catalysis of pre- mRNA splicing has been presented.