R
Rekha G. Panchal
Researcher at United States Department of the Army
Publications - 52
Citations - 2366
Rekha G. Panchal is an academic researcher from United States Department of the Army. The author has contributed to research in topics: Ebola virus & Bacillus anthracis. The author has an hindex of 23, co-authored 51 publications receiving 2144 citations. Previous affiliations of Rekha G. Panchal include Science Applications International Corporation & National Institute of Standards and Technology.
Papers
More filters
Journal ArticleDOI
L1000CDS2: LINCS L1000 characteristic direction signatures search engine
Qiaonan Duan,St. Patrick Reid,Neil R. Clark,Zichen Wang,Nicolas F. Fernandez,Andrew D. Rouillard,Ben Readhead,Sarah R. Tritsch,Rachel A. Hodos,Marc Hafner,Mario Niepel,Peter K. Sorger,Joel T. Dudley,Sina Bavari,Rekha G. Panchal,Avi Ma'ayan +15 more
TL;DR: It is demonstrated that processing the L1000 data with the characteristic direction (CD) method significantly improves signal to noise compared with the MODZ method currently used to compute L1000 signatures.
Journal ArticleDOI
Evaluation of Ebola Virus Inhibitors for Drug Repurposing.
Peter B. Madrid,Rekha G. Panchal,Travis K. Warren,Amy C. Shurtleff,Aaron N. Endsley,Carol E. Green,Andrey A. Kolokoltsov,Robert A. Davey,Ian D. Manger,Lynne Gilfillan,Sina Bavari,Mary J. Tanga +11 more
TL;DR: The results show the benefits and specific challenges associated with drug repurposing and highlight the need for careful evaluation of approved drugs as rapidly deployable countermeasures against future pandemics.
Journal ArticleDOI
In vivo oligomerization and raft localization of Ebola virus protein VP40 during vesicular budding
Rekha G. Panchal,Gordon Ruthel,Tara Kenny,George Kallstrom,Douglas Lane,Shirin S. Badie,Limin Li,Sina Bavari,M. Javad Aman +8 more
TL;DR: By mutagenesis, this work identifies several critical C-terminal sequences that regulate oligomerization at the plasma membrane, association with detergent-resistant membranes, and vesicular release of VP40, directly linking these phenomena.
Journal ArticleDOI
Rational design of small molecules as vaccine adjuvants
Tom Y.-H. Wu,Manmohan Singh,Miller Andrew T,Ennio De Gregorio,Francesco Doro,Ugo D'Oro,David A. G. Skibinski,M. Lamine Mbow,Simone Bufali,Ann E. Herman,Alex Cortez,Yongkai Li,Bishnu P. Nayak,Elaine Tritto,Christophe M. Filippi,Gillis R. Otten,Luis Brito,Elisabetta Monaci,Chun Li,Susanna Aprea,Sara Valentini,Samuele Calabrό,Donatello Laera,Brunella Brunelli,Elena Caproni,Padma Malyala,Rekha G. Panchal,Travis K. Warren,Sina Bavari,Derek T. O'Hagan,Michael P. Cooke,Nicholas Valiante +31 more
TL;DR: In vivo potency can be increased with little to no systemic exposure, localized innate immune activation and short in vivo residence times of SMIP-based adjuvants, and this work provides a systematic and generalizable approach to engineering small molecules for use as vaccine adjuvant.
Journal ArticleDOI
Identification of small molecule inhibitors of anthrax lethal factor
Rekha G. Panchal,Ann R. Hermone,Tam Luong Nguyen,Thiang Yian Wong,Robert Schwarzenbacher,James J. Schmidt,Douglas Lane,Connor F. McGrath,Benjamin E. Turk,James C. Burnett,M. Javad Aman,Stephen F. Little,Edward A. Sausville,Daniel W. Zaharevitz,Lewis C. Cantley,Robert C. Liddington,Rick Gussio,Sina Bavari +17 more
TL;DR: Six inhibitors of LF are described on the basis of a pharmacophoric relationship determined using X-ray crystallographic data, molecular docking studies and three-dimensional (3D) database mining from the US National Cancer Institute (NCI) chemical repository.