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Showing papers by "Renata Cifkova published in 2018"



01 Jan 2018
TL;DR: Change in mean blood pressure is the main driver of the worldwide change in the prevalence of raised blood pressure, but change inThe high-blood-pressure tail of the distribution has also contributed to the change in prevalence, especially in older age groups.

66 citations


Journal ArticleDOI
Majid Ezzati1, Bin Zhou1, James Bentham2, Mariachiara Di Cesare3  +843 moreInstitutions (115)
TL;DR: In this paper, the authors used a linear mixed effect model to quantify the association between the prevalence of raised blood pressure and age-group- and sex-specific mean blood pressure.
Abstract: Background: Change in the prevalence of raised blood pressure could be due to both shifts in the entire distribution of blood pressure (representing the combined effects of public health interventions and secular trends) and changes in its high-blood-pressure tail (representing successful clinical interventions to control blood pressure in the hypertensive population). Our aim was to quantify the contributions of these two phenomena to the worldwide trends in the prevalence of raised blood pressure. Methods: We pooled 1018 population-based studies with blood pressure measurements on 88.6 million participants from 1985 to 2016. We first calculated mean systolic blood pressure (SBP), mean diastolic blood pressure (DBP) and prevalence of raised blood pressure by sex and 10-year age group from 20-29 years to 70-79 years in each study, taking into account complex survey design and survey sample weights, where relevant. We used a linear mixed effect model to quantify the association between (probittransformed) prevalence of raised blood pressure and age-group- and sex-specific mean blood pressure. We calculated the contributions of change in mean SBP and DBP, and of change in the prevalence-mean association, to the change in prevalence of raised blood pressure. Results: In 2005-16, at the same level of population mean SBP and DBP, men and women in South Asia and in Central Asia, the Middle East and North Africa would have the highest prevalence of raised blood pressure, and men and women in the highincome Asia Pacific and high-income Western regions would have the lowest. In most region-sex-age groups where the prevalence of raised blood pressure declined, one half or more of the decline was due to the decline in mean blood pressure. Where prevalence of raised blood pressure has increased, the change was entirely driven by increasing mean blood pressure, offset partly by the change in the prevalence-mean association. Conclusions: Change in mean blood pressure is the main driver of the worldwide change in the prevalence of raised blood pressure, but change in the high-blood-pressure tail of the distribution has also contributed to the change in prevalence, especially in older age groups.

58 citations


Journal ArticleDOI
TL;DR: Cardiovascular risk factors are highly prevalent in the city of Brno, an urban population from Central Europe, and the Kardiovize Brno 2030 study will provide unique multidimensional and longitudinal cardiovascular health data from a region where epidemiological studies are scarce.
Abstract: BackgroundAtherosclerotic cardiovascular disease is highly prevalent in Eastern and Central Europe, where the incidence is the highest in the world. The Kardiovize Brno 2030 study was designed as a...

42 citations



Journal ArticleDOI
TL;DR: The co-incidence of MetS has a limited mortality impact in CHD patients, while an increase in fasting glycemia seems to be more a specific marker of mortality risk.

11 citations


Journal ArticleDOI
TL;DR: Low vitamin D status was in virtually healthy subjects associated with decreased insulin sensitivity, namely in those with GG genotype of rs2228570 VDR polymorphism, and possible interaction with vitamin D receptor (VDR) polymorphism.
Abstract: Low vitamin D status has been frequently associated with impaired glucose metabolism. We examined associations between 25-hydroxyvitamin D (25-OH-D) and several parameters of glucose homeostasis in virtually healthy subjects, and explored possible interaction with vitamin D receptor (VDR) polymorphism. Nondiabetic subjects without chronic medication or any known significant manifest disease were selected from large general-population based population survey. Insulin sensitivity and β cell secretion were calculated by homeostasis model assessment (HOMA) and soluble isoform of receptor for advanced glycation end-products (sRAGE) using commercial ELISA. Subjects were also genotyped for rs2228570 polymorphism of VDR. After adjustment for potential confounders, we observed a significant relationship between 25-OH-D and fasting glycemia (β coefficient=–5.904; p=0.002) or insulin sensitivity (β=0.042; p=0.001), but not with β cell secretion or sRAGE. We found also an interaction with VDR polymorphism. Subjects with low 25-OH-D and AA genotype had significantly lower insulin sensitivity than those with GG genotype plus highest 25-OH-D concentrations (107.3% vs. 183.9%, p=0.021). In conclusion, low vitamin D status was in virtually healthy subjects associated with decreased insulin sensitivity, namely in those with GG genotype of rs2228570 VDR polymorphism.

11 citations


Journal ArticleDOI
TL;DR: Gestational hypertension, and preeclampsia in pregnancy are the most common medical complications of pregnancy, affecting 5% to 10% of pregnancies, and it has been long believed that all the problems of gestational hypertension get solved within 6 weeks postpartum.
Abstract: Hypertensive disorders in pregnancy are the most common medical complications of pregnancy, affecting 5% to 10% of pregnancies. It has been long believed that all the problems of gestational hypertension get solved within 6 weeks postpartum. However, gestational hypertension, and preeclampsia in

8 citations


Journal ArticleDOI
TL;DR: Odborne stanovisko výboru Ceske spolecnosti pro aterosklerozu k doporucenim ESC/EAS pro diagnostiku a lecbu dyslipidemii z roku 2016 as mentioned in this paper.
Abstract: Odborne stanovisko výboru Ceske spolecnosti pro aterosklerozu k doporucenim ESC/EAS pro diagnostiku a lecbu dyslipidemii z roku 2016..

7 citations


Journal ArticleDOI
TL;DR: Women with preexisting hypertension, long duration of antihypertensive treatment in pregnancy, higher maximum systolic and diastolic BP levels, higher body mass index, or occurrence of preterm eclampsia are more likely to have sustained hypertension after delivery.
Abstract: See related article, pp 103–109 Hypertensive disorders complicate 5% to 10% of pregnancies, and preeclampsia occurs in 3% to 5% of all pregnancies. Gestational hypertension, including preeclampsia, should, by definition, resolve within 6 weeks postpartum. There is some evidence, mostly from retrospective studies, that elevated blood pressure (BP) normalizes within days of delivery in most women. Women with preexisting hypertension, long duration of antihypertensive treatment in pregnancy, higher maximum systolic and diastolic BP levels, higher body mass index, or occurrence of preterm eclampsia are more likely to have sustained hypertension after delivery.1–3 Ditisheim et al4 conducted a prospective cohort study in 115 women with preeclampsia and 41 control subjects with physiological pregnancy in whom office BP and 24-hour ambulatory BP monitoring (ABPM) were performed 6 to 12 weeks after delivery. Preeclampsia was defined, according to the revised statement from the International Society for the Study of Hypertension in Pregnancy,5 as new-onset …

2 citations