R
Renata Pasqualini
Researcher at University of Texas MD Anderson Cancer Center
Publications - 49
Citations - 13356
Renata Pasqualini is an academic researcher from University of Texas MD Anderson Cancer Center. The author has contributed to research in topics: Medicine & Phage display. The author has an hindex of 29, co-authored 35 publications receiving 12807 citations. Previous affiliations of Renata Pasqualini include Vita-Salute San Raffaele University & Sanford-Burnham Institute for Medical Research.
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Journal ArticleDOI
Cancer Treatment by Targeted Drug Delivery to Tumor Vasculature in a Mouse Model
TL;DR: In vivo selection of phage display libraries was used to isolate peptides that home specifically to tumor blood vessels that enhanced the efficacy of the anticancer drug doxorubicin and reduced its toxicity.
Journal ArticleDOI
Organ targeting In vivo using phage display peptide libraries
TL;DR: A new approach to studying organ-selective targeting based on in vivoscreening of random peptide sequences is reported, which represents the first step towards identifying selective endothelial markers, which may be useful in targeting cells, drugs and genes into selected tissues.
Journal ArticleDOI
Anti-cancer activity of targeted pro-apoptotic peptides
H. Michael Ellerby,H. Michael Ellerby,Wadih Arap,Lisa M. Ellerby,Lisa M. Ellerby,Renate Kain,Renate Kain,Rebecca L. Andrusiak,Gabriel del Rio,Gabriel del Rio,Stanislaw Krajewski,Christian R. Lombardo,Rammohan V. Rao,Rammohan V. Rao,Erkki Ruoslahti,Dale E. Bredesen,Dale E. Bredesen,Renata Pasqualini +17 more
TL;DR: Short peptides composed of two functional domains, one a tumor blood vessel 'homing' motif and the other a programmed cell death-inducing sequence, are designed and synthesized by simple peptide chemistry and may yield new therapeutic agents.
Journal Article
Aminopeptidase N Is a Receptor for Tumor-homing Peptides and a Target for Inhibiting Angiogenesis
Renata Pasqualini,Erkki Koivunen,Renate Kain,Johanna Lahdenranta,Johanna Lahdenranta,Michiie Sakamoto,Michiie Sakamoto,Anette Stryhn,Richard A. Ashmun,Linda H. Shapiro,Wadih Arap,Erkki Ruoslahti +11 more
TL;DR: It is shown here that the receptor for the NGR peptides in tumor vasculature is aminopeptidase N (APN; also called CD13), and APN is involved in angiogenesis and can serve as a target for delivering drugs into tumors and for inhibitingAngiogenesis.
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αv Integrins as receptors for tumor targeting by circulating ligands
TL;DR: Results show that the αv Integrins present in tumor blood vessels can bind circulating ligands and that RGD peptides selective for these integrins may be suitable tools in tumor targeting for diagnostic and therapeutic purposes.