R
Renato L. Santos
Researcher at Universidade Federal de Minas Gerais
Publications - 270
Citations - 8830
Renato L. Santos is an academic researcher from Universidade Federal de Minas Gerais. The author has contributed to research in topics: Brucella ovis & Visceral leishmaniasis. The author has an hindex of 45, co-authored 252 publications receiving 7792 citations. Previous affiliations of Renato L. Santos include University of California, Davis & Texas A&M University.
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Journal ArticleDOI
Simian immunodeficiency virus-induced mucosal interleukin-17 deficiency promotes Salmonella dissemination from the gut
Manuela Raffatellu,Renato L. Santos,David Verhoeven,Michael D. George,R. Paul Wilson,Sebastian E. Winter,Ivan Godinez,Sumathi Sankaran,Tatiane A. Paixão,Melita A. Gordon,Jay K. Kolls,Satya Dandekar,Andreas J. Bäumler +12 more
TL;DR: It is shown that simian immunodeficiency virus (SIV) infection results in depletion of T helper type 17 (TH17) cells in the ileal mucosa of rhesus macaques, thereby impairing mucosal barrier functions to S. typhimurium dissemination.
Journal ArticleDOI
Animal models of Salmonella infections: enteritis versus typhoid fever
Renato L. Santos,Shuping Zhang,Renée M. Tsolis,Robert A. Kingsley,L. Garry Adams,Andreas J. Bäumler +5 more
TL;DR: This article reviews murine typhoid and bovine enteritis and discusses strengths, limitations and distinctive features of these animal models.
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Lipocalin-2 resistance confers an advantage to Salmonella enterica serotype Typhimurium for growth and survival in the inflamed intestine.
Manuela Raffatellu,Manuela Raffatellu,Michael D. George,Yuko Akiyama,Michael Hornsby,Sean Paul Nuccio,Tatiane A. Paixão,Brian P. Butler,Hiutung Chu,Renato L. Santos,Thorsten Berger,Tak W. Mak,Renée M. Tsolis,Charles L. Bevins,Jay V. Solnick,Satya Dandekar,Andreas J. Bäumler +16 more
TL;DR: It is reported that enteric infection of rhesus macaques and mice with S. Typhimurium resulted in marked Il-17- and IL-22-dependent intestinal epithelial induction and luminal accumulation of lipocalin-2, an antimicrobial protein that prevents bacterial iron acquisition.
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Molecular Pathogenesis of Salmonella enterica Serotype Typhimurium-Induced Diarrhea
Shuping Zhang,Robert A. Kingsley,Renato L. Santos,Helene Andrews-Polymenis,Manuela Raffatellu,Josely F. Figueiredo,Jairo Nunes,Renée M. Tsolis,L. Garry Adams,Andreas J. Bäumler +9 more
TL;DR: Improved understanding of key events occurring during the complex series of host-pathogen interactions leading to enterocolitis is led to an improved understanding of the molecular pathogenesis.
Journal ArticleDOI
The Salmonella enterica serotype Typhimurium effector proteins SipA, SopA, SopB, SopD, and SopE2 act in concert to induce diarrhea in calves
Shuping Zhang,Renato L. Santos,Renée M. Tsolis,Silke Stender,Wolf-Dietrich Hardt,Andreas J. Bäumler,L. Garry Adams +6 more
TL;DR: SipA, Sop a, SopB, SopD, and SopE2 are major virulence factors responsible for diarrhea during Salmonella serotype Typhimurium infection of calves, and a positive correlation was observed between the severity of histopathological lesions detected in the ileal mucosa and the levels of fluid accumulation induced by the different mutants.