Author
Renault Olivier
Other affiliations: Renault
Bio: Renault Olivier is an academic researcher from University of Caen Lower Normandy. The author has contributed to research in topics: Aryl & Alkyl. The author has an hindex of 5, co-authored 15 publications receiving 70 citations. Previous affiliations of Renault Olivier include Renault.
Topics: Aryl, Alkyl, Friedel–Crafts reaction, Diketone, Curtius rearrangement
Papers
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TL;DR: A series of 22 cyclopenta[c]thiophene related compounds were obtained by the pharmacomodulation of 6-amino-5,6-dihydro-4H-cyclopenta-4-ones 1a-g as discussed by the authors.
28 citations
TL;DR: In this article, the synthesis of 2-aryl-6-methyl-2,3-dihydro-1H-pyridin-4-ones was achieved starting from corresponding β-aryl β-amino acids.
14 citations
TL;DR: In this paper, the synthesis of new analogues of methylphenidate and modafinil, derived from 3-amino-3-arylpropionic acids, was described.
Abstract: The synthesis of new analogues of methylphenidate and modafinil, derived from 3-amino-3-arylpropionic acids, is described. Central pharmacological properties were studied in mice.
10 citations
7 citations
5 citations
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TL;DR: 1. Six-Membered Heterocycles with One Heteroatom 4155 7.6.1.
Abstract: 6.1. Oxadiazoles 4154 6.2. Diazaphospholes 4154 7. Six-Membered Heterocycles with One Heteroatom 4155 7.1. Pyridines 4155 7.2. Pyridinones 4155 7.3. Quinolines 4156 7.4. Quinolinones 4157 7.5. Isoquinolines 4157 7.6. Acridines 4158 7.7. Pyranones 4158 7.8. Flavones 4159 8. Six-Membered Heterocycles with Two Heteroatoms 4159 8.1. Pyridazinones 4159 8.2. Pyrimidines 4159 8.3. Pyrimidinones 4160 8.4. Quinazolines 4162 8.5. Quinazolinones 4162 8.6. Quinoxalines 4164 8.7. Quinoxalinediones 4165 8.8. Oxazines 4165 8.9. Oxazinones 4166 8.10. Thiazines 4166 9. Six-Membered Heterocycles with Three Heteroatoms 4166
549 citations
384 citations
TL;DR: A novel and facile route to functionalized mono/bicyclic 2,3-dihydro-4-pyridones has been developed via formal [5C + 1N] annulation of readily available alpha-alkenoyl ketene-(S,S)-acetals with various aliphatic primary amines.
82 citations
TL;DR: The present review has presented the information available on thiophene-based molecules as anticancer agents with special focus on synthetic methodologies, biological profile and structure activity relationship (SAR) studies.
58 citations
TL;DR: A simple and efficient direct enzymatic method was developed for the synthesis of 4-aryl-substituted β-lactams and the corresponding β-amino acid enantiomers through the CAL-B (lipase B from Candida antarctica)-catalyzed enantioselective ring cleavage of the corresponding racemic β- lactams.
Abstract: A simple and efficient direct enzymatic method was developed for the synthesis of 4-aryl-substituted β-lactams and the corresponding β-amino acid enantiomers through the CAL-B (lipase B from Candida antarctica)-catalyzed enantioselective (E> 200) ring cleavage of the corresponding racemic β-lactams with 1 equiv. of H 2 O in i-Pr 2 O at 60°C. The product (R)-β-amino acids (ee>98%, yields ≥42%) and unreacted (S)-β-lactams (ee≥95%, yields≥ 41%) could be easily separated. The ring opening of enantiomeric β-lactams with 18% HCl afforded the corresponding enantiopure β-amino acid hydrochlorides (ee ≥ 99%).
47 citations