Renhua Huang

TL;DR: The present study is the first to establish thatAHIF promotes glioblastoma progression and radioresistance via exosomes, which suggests that AHIF is a potential therapeutic target for GBM.

TL;DR: It is found that a novel LGMN pseudogene (LGM NP1) was upregulated in glioblastoma (GBM) tissues and high LGMNP1 expression in GBM cells enhanced proliferation and invasion and CeRNA-mediated miRNA sequestration might be a novel therapeutic strategy in G BM.

TL;DR: In this paper, the authors found that circLGMN was the most abundantly expressed circRNA derived from Legumain and showed that LGMN overexpression promoted GBM cell proliferation and enhanced cell invasion.

TL;DR: In this article, the antisense transcript of hypoxia-inducible factor-1α (AHIF) was upregulated in glioblastoma multiforme (GBM) cells after radiotherapy.

TL;DR: In vitro mechanistic studies indicated that the MSNs@anti-IL-1β can regulate the macrophage-related inflammatory microenvironment, promote the viability of vascular endothelial cells (vECs), and reduce proliferation and phenotypic switching of vascular smooth muscle cells ( vSMCs) and taken together, these MSNs affording the sustained release of anti-cytokine agents may have broad implications for the clinical management of the AS.