R
Ricardo Martinez
Researcher at National University of San Juan
Publications - 175
Citations - 18660
Ricardo Martinez is an academic researcher from National University of San Juan. The author has contributed to research in topics: Catalysis & Furfuryl alcohol. The author has an hindex of 42, co-authored 166 publications receiving 17217 citations. Previous affiliations of Ricardo Martinez include Massachusetts Institute of Technology & Pontifical Catholic University of Chile.
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Journal ArticleDOI
The Protein Kinase Complement of the Human Genome
TL;DR: The protein kinase complement of the human genome is catalogued using public and proprietary genomic, complementary DNA, and expressed sequence tag sequences to provide a starting point for comprehensive analysis of protein phosphorylation in normal and disease states and a detailed view of the current state of human genome analysis through a focus on one large gene family.
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High affinity VEGF binding and developmental expression suggest Flk-1 as a major regulator of vasculogenesis and angiogenesis.
Birgit Millauer,Susanne Wizigmann-Voos,Harald Schnürch,Ricardo Martinez,Niels Møller,Werner Risau,Axel Ullrich +6 more
TL;DR: Investigation of flk-1 receptor tyrosine kinase mRNA expression by in situ hybridization analysis revealed specific association with endothelial cells at all stages of mouse development, suggesting a major role of this ligand-receptor signaling system in vasculogenesis and angiogenesis.
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Protein tyrosine kinase PYK2 involved in Ca 2+ -induced regulation of ion channel and MAP kinase functions
Sima Lev,Herman Moreno,Ricardo Martinez,Peter Canoll,Elior Peles,JoséM. Musacchio,Gregory D. Plowman,Bernardo Rudy,Joseph Schlessinger +8 more
TL;DR: PYK2 activation may provide a mechanism for a variety of short- and long-term calcium-dependent signalling events in the nervous system.
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Efficacy and Safety of Abemaciclib, an Inhibitor of CDK4 and CDK6, for Patients with Breast Cancer, Non–Small Cell Lung Cancer, and Other Solid Tumors
Amita Patnaik,Lee S. Rosen,Sara M. Tolaney,Anthony W. Tolcher,Jonathan W. Goldman,Leena Gandhi,Kyriakos P. Papadopoulos,Muralidhar Beeram,Drew W. Rasco,John Hilton,Aejaz Nasir,Richard P. Beckmann,Andrew E. Schade,Angie D. Fulford,Tuan S. Nguyen,Ricardo Martinez,Palaniappan Kulanthaivel,Lily Q. Li,Martin Frenzel,Damien M. Cronier,Edward M. Chan,Keith T. Flaherty,Patrick Y. Wen,Geoffrey I. Shapiro +23 more
TL;DR: Abemaciclib represents the first selective inhibitor of CDK4 and CDK6 with a safety profile allowing continuous dosing to achieve sustained target inhibition, and this first-in-human experience demonstrates single-agent activity for patients with advanced breast cancer, NSCLC, and other solid tumors.
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Caspr2, a New Member of the Neurexin Superfamily, Is Localized at the Juxtaparanodes of Myelinated Axons and Associates with K+ Channels
Sebastian Poliak,Leora Gollan,Ricardo Martinez,Andrew W. Custer,Steven Einheber,James L. Salzer,James S. Trimmer,Peter Shrager,Elior Peles +8 more
TL;DR: A role for Caspr family members in the local differentiation of the axon into distinct functional subdomains is suggested in the generation of specialized subcellular domains to which different sets of ion channels are localized.