Riccardo Bocchi

TL;DR: It is revealed that, in the developing mouse neocortex, ventricular zone progenitors become more hyperpolarized as they generate successive subtypes of neurons.

TL;DR: A stab wound injury covering an entire neocortical column and targeted local reactive astrocytes via injecting FLEx switch (Cre-On) adeno-associated viral (AAV) vectors into mGFAP-Cre mice resulted in high-efficiency reprogramming of targeted astroCytes into neurons that develop lamina-specific hallmarks, including the appropriate long-distance axonal projections.

TL;DR: It is demonstrated using constitutive and conditional genetic strategies that transient downregulation of canonical Wnt/β-catenin signaling during the multipolar stage plays a critical role in polarizing and orienting cells for radial migration.

TL;DR: It is shown that Wnt/C-Kit signaling regulates radial migration in rat somatosensory cortex, and that transient delay of L2/3 neuronal migration leads to interhemispheric connectivity alteration and abnormal social behavior.

TL;DR: In this paper, the authors proposed a molecular program for neuronal subtype specification, allowing engineering of more precise neuronal subtypes and disentangling subtype diversity from dynamic transcriptional states.