R
Richard A. Flavell
Researcher at Yale University
Publications - 1389
Citations - 223064
Richard A. Flavell is an academic researcher from Yale University. The author has contributed to research in topics: Immune system & T cell. The author has an hindex of 231, co-authored 1328 publications receiving 205119 citations. Previous affiliations of Richard A. Flavell include National Institute for Medical Research & University of Michigan.
Papers
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Journal ArticleDOI
Modulation of cell adhesion and motility in the immune system by Myo1f.
Sangwon V. Kim,Wajahat Z. Mehal,Xuemei Dong,Volkmar Heinrich,Marc Pypaert,Marc Pypaert,Ira Mellman,Ira Mellman,Micah Dembo,Mark S. Mooseker,Dianqing Wu,Richard A. Flavell +11 more
TL;DR: It is demonstrated that one of these proteins, Myo1f, is expressed predominantly in the mammalian immune system and directs immune cell motility and innate host defense against infection.
Journal ArticleDOI
Mitogen-activated protein kinase kinase 3 is a pivotal pathway regulating p38 activation in inflammatory arthritis.
Tomoyuki Inoue,David L. Boyle,Maripat Corr,Deepa Hammaker,Roger J. Davis,Richard A. Flavell,Gary S. Firestein +6 more
TL;DR: Selective MKK3 deficiency can suppress inflammatory arthritis and cytokine production while Toll-like receptor 4-mediated host defense remains intact.
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The activation of major histocompatibility complex class I genes by interferon regulatory factor-1 (IRF-1).
TL;DR: Data suggest that IRF-1 is involved in the IFN-γ mediated induction of MHC class I expression, and appears to be direct and sequence-specific.
Journal Article
Cutting Edge: Sustained Expansion of CD8+ T Cells Requires CD154 Expression by Th Cells in Acute Graft Versus Host Disease
Janet E. Buhlmann,Mercedes Gonzalez,Brigit Ginther,Angela Panoskaltsis-Mortari,Bruce R. Blazar,Dale L. Greiner,Aldo A. Rossini,Richard A. Flavell,Randolph J. Noelle +8 more
TL;DR: Observations suggest alphaCD154 therapy in GvHD is effective because the treatment causes an abortive CD8 alloresponse leading to the exhaustion or deletion of alloreactive CD8+ clones preventing the development of disease.
Journal ArticleDOI
A Novel Role for GADD45β as a Mediator of MMP-13 Gene Expression during Chondrocyte Terminal Differentiation
Kosei Ijiri,Luiz F. Zerbini,Haibing Peng,Ricardo G. Correa,Binfeng Lu,Nicole C. Walsh,Yani Zhao,Noboru Taniguchi,Xuling Huang,Hasan H. Otu,Hong Wang,Jian Fei Wang,Setsuro Komiya,Patricia Ducy,Mahboob U. Rahman,Richard A. Flavell,Ellen M. Gravallese,Peter Oettgen,Towia A. Libermann,Mary B. Goldring +19 more
TL;DR: The unexpected expression of GADD45β in the embryonic growth plate is demonstrated and its novel role as an essential mediator of matrix metalloproteinase-13 (MMP-13) expression during terminal chondrocyte differentiation is uncovered.