R
Richard A. Flavell
Researcher at Yale University
Publications - 1389
Citations - 223064
Richard A. Flavell is an academic researcher from Yale University. The author has contributed to research in topics: Immune system & T cell. The author has an hindex of 231, co-authored 1328 publications receiving 205119 citations. Previous affiliations of Richard A. Flavell include National Institute for Medical Research & University of Michigan.
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Journal ArticleDOI
Structure of the human fetal globin gene locus
TL;DR: A ‘map’ of restriction enzyme sites in and around the human γ-globin genes is derived and it is concluded that the correct gene organisation of the human β-like globin locus is GγAγδβ.
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Natural killer T cells exacerbate liver injury in a transforming growth factor β receptor II dominant-negative mouse model of primary biliary cirrhosis†
Ya-Hui Chuang,Ya-Hui Chuang,Zhe-Xiong Lian,Guo Xiang Yang,Shang An Shu,Yuki Moritoki,William M. Ridgway,Aftab A. Ansari,Mitchell Kronenberg,Richard A. Flavell,Bin Gao,M. Eric Gershwin +11 more
TL;DR: It is demonstrated that CD1d‐restricted NKT cells in dnTGFβRII mice are a critical factor in liver injury.
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Arthritogenic Properties of Double-Stranded (Viral) RNA
Fariba Zare,Maria Bokarewa,Nancy Nenonen,Thomas Bergström,Lena Alexopoulou,Richard A. Flavell,Richard A. Flavell,Andrej Tarkowski +7 more
TL;DR: It is demonstrated that viral dsRNA is clearly arthritogenic, and macrophages and their products play an important role in the development of arthritis triggered by ds RNA, which was triggered through IL-1R signaling.
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Adenosine is required for sustained inflammasome activation via the A₂A receptor and the HIF-1α pathway.
Xinshou Ouyang,Ayaz Ghani,Ahsan F. Malik,Tuere Wilder,Oscar R. Colegio,Richard A. Flavell,Bruce N. Cronstein,Wajahat Z. Mehal +7 more
TL;DR: It is reported that adenosine is a key regulator of inflammasome activity, increasing the duration of the inflammatory response via the A2A receptor, and sustained, after initial activation, by A 2A receptor-mediated signalling.
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A Scaffold Protein, AHNAK1, Is Required for Calcium Signaling during T Cell Activation
Didi Matza,Abdallah Badou,Koichi Kobayashi,Karen Goldsmith-Pestana,Yutaka Masuda,Akihiko Komuro,Diane McMahon-Pratt,Vincent T. Marchesi,Richard A. Flavell +8 more
TL;DR: AHNAK1 plays an essential role in T cell Ca2+ signaling through Cav1 channels, triggered via TCR activation; therefore, AHNAK 1 is a potential target for therapeutic intervention.