R
Richard A. Flavell
Researcher at Yale University
Publications - 1389
Citations - 223064
Richard A. Flavell is an academic researcher from Yale University. The author has contributed to research in topics: Immune system & T cell. The author has an hindex of 231, co-authored 1328 publications receiving 205119 citations. Previous affiliations of Richard A. Flavell include National Institute for Medical Research & University of Michigan.
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Journal ArticleDOI
IL-10 signaling blockade controls murine West Nile virus infection.
Fengwei Bai,Terrence Town,Terrence Town,Terrence Town,Feng Qian,Penghua Wang,Masahito Kamanaka,Tarah M. Connolly,David Gate,Ruth R. Montgomery,Richard A. Flavell,Erol Fikrig +11 more
TL;DR: It is found that WNV infection is markedly diminished in IL-10 deficient (IL-10−/−) mice, and pharmacologic blockade of Il-10 signaling by IL- 10 neutralizing antibody increases survival of WNV-infected mice, suggesting a novel anti-WNV therapeutic strategy.
Journal ArticleDOI
Oxidative metabolism enables Salmonella evasion of the NLRP3 inflammasome
Meghan A. Wynosky-Dolfi,Annelise G. Snyder,Naomi H. Philip,Patrick J. Doonan,Maya C. Poffenberger,Daina Avizonis,Erin E. Zwack,Amber M. Riblett,Baofeng Hu,Till Strowig,Richard A. Flavell,Russell G. Jones,Bruce D. Freedman,Igor E. Brodsky +13 more
TL;DR: Salmonella lacking the TCA enzyme aconitase trigger NLRP3 inflammasome activation in infected macrophages, leading to elevated inflammatory responses and reduced virulence.
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Deletion of interleukin (IL)-12p35 induces liver fibrosis in dominant-negative TGFβ receptor type II mice
Masanobu Tsuda,Masanobu Tsuda,Weici Zhang,Guo-Xiang Yang,Koichi Tsuneyama,Koichi Tsuneyama,Yugo Ando,Kazuhito Kawata,Ogyi Park,Patrick S.C. Leung,Ross L. Coppel,Aftab A. Ansari,William M. Ridgway,Bin Gao,Zhe-Xiong Lian,Zhe-Xiong Lian,Richard A. Flavell,Xiao-Song He,M. Eric Gershwin +18 more
TL;DR: IL‐12p35−/− dnTGFβRII mice, histologically and immunologically, reflect key features of PBC, providing a useful generic model to understand the immunopathology of human PBC.
Journal ArticleDOI
Contribution of Fas to diabetes development
Alexei Y. Savinov,Andrew Tcherepanov,E. Allison Green,Richard A. Flavell,Alexander V. Chervonsky +4 more
TL;DR: Both Fas-dependent and -independent mechanisms are involved in beta cell destruction, but interference with the Fas pathway early in disease development may retard or prevent diabetes progression.
Journal ArticleDOI
NLRC4/IPAF: a CARD carrying member of the NLR family.
TL;DR: A review of findings show that the NLR family member NLRC4 (also known as IPAF) has important roles in innate immune responses to Gram-negative bacteria as well as the role of bacterial type III and type IV secretion systems and flagellin inNLRC4-mediated caspase-1 activation.